2. Stem Cell/Wnt TGF-beta/Smad
  3. TGF-beta/Smad
  4. (E/Z)-SIS3 free base

E/Z-SIS3 free base exhibits an inhibitory efficacy against smad3, exhibits an anti-fibrotic and anti-inflammatory effect through a TGF-β/smad3 signaling pathway.

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(E/Z)-SIS3 free base Chemical Structure

(E/Z)-SIS3 free base Chemical Structure

CAS No. : 1009104-85-1

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(E/Z)-SIS3 free base Related Antibodies

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Description

E/Z-SIS3 free base exhibits an inhibitory efficacy against smad3, exhibits an anti-fibrotic and anti-inflammatory effect through a TGF-β/smad3 signaling pathway[1].

In Vivo

E/Z-SIS3 free base (2 mg/kg, i.p.) inhibits smad3 phosphorylation and levels of TGF-β1, ameliorates bleomycin (BLM)-induced pulmonary fibrosis (PF) and inflammation in C57BL/6J mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BLM-induced PF in C57BL/6J mice[1]
Dosage: 2 mg/kg
Administration: i.p., every two days for 3 weeks
Result: Inhibited the fibrosis and collagen deposition in lung.
Reduced numbers of lymphocytes, macrophages, and neutrophils in bronchoalveolar Lavage (BAL).
Molecular Weight

453.53

Formula

C28H27N3O3
CAS No.
SMILES

O=C(N1CC2=CC(OC)=C(C=C2CC1)OC)/C=C/C3=C(C4=CC=CC=C4)N(C)C5=NC=CC=C35
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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(E/Z)-SIS3 free base Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(E/Z)-SIS31009104-85-1TGF-beta/SmadTransforming growth factor betapulmonary fibrosisbleomycinchronic kidney diseaseCKDInhibitorinhibitorinhibit

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(E/Z)-SIS3 free base
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