1. Stem Cell/Wnt
    TGF-beta/Smad
  2. TGF-beta/Smad

SIS3 (Synonyms: SIS 3; SIS-3)

Cat. No.: HY-13013 Purity: >98.0%
Data Sheet SDS Handling Instructions

SIS3 is a potent and selective inhibitor of Smad3. a potent regulator of the human Nox4 promoter.

For research use only. We do not sell to patients.
SIS3 Chemical Structure

SIS3 Chemical Structure

CAS No. : 521984-48-5

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $151 In-stock
2 mg $80 In-stock
5 mg $140 In-stock
10 mg $210 In-stock
25 mg $420 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Description

SIS3 is a potent and selective inhibitor of Smad3. a potent regulator of the human Nox4 promoter. target: Smad3 SIS3 Reduces the TGF-β1-Dependent Increase in Phosphorylation and DNA Binding of Smad3. SIS3 has no effect on Smad2, p38 MAPK, ERK or PI 3-kinase signaling. SIS3 can block excessive ECM production from the TGF-β1-treated normal fibroblasts and scleroderma fibroblasts, the model of cells with autocrine TGF-β signaling in vitro.

References
M.Wt

489.99

Formula

C₂₈H₂₈ClN₃O₃

CAS No.

521984-48-5

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 30 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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SIS3
Cat. No.:
HY-13013
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