1. Stem Cell/Wnt
    TGF-beta/Smad
  2. TGF-beta/Smad
  3. SIS3 free base

SIS3 free base 

Cat. No.: HY-100444
Handling Instructions

SIS3 free base is a potent and selective inhibitor of Smad3 phosphorylation. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1.

For research use only. We do not sell to patients.

SIS3 free base Chemical Structure

SIS3 free base Chemical Structure

CAS No. : 1009104-85-1

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Description

SIS3 free base is a potent and selective inhibitor of Smad3 phosphorylation. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1[1].

IC50 & Target

Smad3, ALK-5[1]

In Vitro

SIS3 free base attenuates the TGF-beta1-induced phosphorylation of Smad3 and interaction of Smad3 with Smad4[1].

Western Blot Analysis[1]

Cell Line: Human dermal fibroblasts
Concentration: 0.3, 1, 3, 10 μM
Incubation Time: For 1 hour
Result: Attenuated the TGF-beta1-induced phosphorylation of Smad3 and interaction of Smad3 with Smad4.
Molecular Weight

453.53

Formula

C₂₈H₂₇N₃O₃

CAS No.

1009104-85-1

SMILES

O=C(/C=C/C1=C(N(C2=NC=CC=C21)C)C3=CC=CC=C3)N4CC5=C(CC4)C=C(C(OC)=C5)OC

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

SIS3SIS 3SIS-3TGF-beta/SmadTransforming growth factor betaSmad3phosphorylationmyofibroblastdifferentiationfibroblastsTGF-β1Inhibitorinhibitorinhibit

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SIS3 free base
Cat. No.:
HY-100444
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