1. Stem Cell/Wnt
    TGF-beta/Smad
  2. TGF-beta/Smad
  3. SIS3 free base

SIS3 free base 

Cat. No.: HY-100444
Handling Instructions

SIS3 free base is a potent and selective inhibitor of Smad3 phosphorylation. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1. SIS3 free base does not affect the phosphorylation of Smad2.

For research use only. We do not sell to patients.

SIS3 free base Chemical Structure

SIS3 free base Chemical Structure

CAS No. : 1009104-85-1

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Description

SIS3 free base is a potent and selective inhibitor of Smad3 phosphorylation. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1. SIS3 free base does not affect the phosphorylation of Smad2[1].

IC50 & Target

Smad3, ALK-5[1]

In Vitro

SIS3 free base attenuates the TGF-beta1-induced phosphorylation of Smad3 and interaction of Smad3 with Smad4[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: Human dermal fibroblasts
Concentration: 0.3, 1, 3, 10 μM
Incubation Time: For 1 hour
Result: Attenuated the TGF-beta1-induced phosphorylation of Smad3 and interaction of Smad3 with Smad4.
Molecular Weight

453.53

Formula

C₂₈H₂₇N₃O₃

CAS No.
SMILES

O=C(/C=C/C1=C(N(C2=NC=CC=C21)C)C3=CC=CC=C3)N4CC5=C(CC4)C=C(C(OC)=C5)OC

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

SIS3SIS 3SIS-3TGF-beta/SmadTransforming growth factor betaSmad3phosphorylationmyofibroblastdifferentiationfibroblastsTGF-β1Inhibitorinhibitorinhibit

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SIS3 free base
Cat. No.:
HY-100444
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