521985-36-4
521985-36-4
Chemical Structure
SIS3 free base
- CAS No.: 521985-36-4
- Formula:C28H27N3O3
- Molecular Weight:453.53
IUPAC Name: (E)-1-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one
InChIKey: IJYPHMXWKKKHGT-VAWYXSNFSA-N
SMILES: O=C(/C=C/C1=C(N(C2=NC=CC=C21)C)C3=CC=CC=C3)N4CC5=C(CC4)C=C(C(OC)=C5)OC
Biological Activity: SIS3 free base is a potent and selective inhibitor of Smad3 phosphorylation. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1. SIS3 free base does not affect the phosphorylation of Smad2[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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SIS3 free base | 98.02% | SIS3 free base is a potent and selective inhibitor of Smad3 phosphorylation. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1. SIS3 free base does not affect the phosphorylation of Smad2. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.99
HY-13013SIS3 -
Similarity Score 0.54
HY-160115TDP-43 degrader-1 -
Similarity Score 0.52
HY-161260P-gp inhibitor 20 -
Similarity Score 0.52
HY-161846Tyrosinase-IN-31 -
Similarity Score 0.51
HY-155315Tubulin polymerization-IN-51 -
Similarity Score 0.50
HY-175838P-gp-IN-32 -
Similarity Score 0.50
HY-145628CM398 -
Similarity Score 0.49
HY-163794DC371739 -
Similarity Score 0.49
HY-101791P-gp inhibitor 1 -
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