country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-155315

Copy Link Print Information

Tubulin polymerization-IN-51

Tubulin polymerization-IN-51(compound 7u) is a tubulin polymerization inhibitor with IC₅₀ value of 2.55 - 17.89μM for SK-Mel-28 cells. Tubulin polymerization-IN-51 can be used for cancer research.

For research use only. We do not sell to patients.

CAS No.: 2998928-27-9
Formula: C₂₆H₂₅N₃O₃
Molecular Weight:427.50

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Tubulin polymerization-IN-51 Chemical Structure

CAS No.: 2998928-27-9

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	5.5 μM Compound: 7u	Anticancer activity against human A549 cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay Anticancer activity against human A549 cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay	[PMID: 37797804]
B16-F10	IC₅₀	4.76 μM Compound: 7u	Anticancer activity against mouse B16-F10 cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay Anticancer activity against mouse B16-F10 cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay	[PMID: 37797804]
HCT-116	IC₅₀	6.04 μM Compound: 7u	Anticancer activity against human HCT-116 cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay Anticancer activity against human HCT-116 cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay	[PMID: 37797804]
MCF7	IC₅₀	5.9 μM Compound: 7u	Anticancer activity against human MCF7 cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay Anticancer activity against human MCF7 cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay	[PMID: 37797804]
NRK-52E	IC₅₀	51.85 μM Compound: 7u	Cytotoxicity against NRK-52E cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay Cytotoxicity against NRK-52E cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay	[PMID: 37797804]
SK-MEL-28	IC₅₀	2.55 μM Compound: 7u	Anticancer activity against human SK-MEL-28 cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay Anticancer activity against human SK-MEL-28 cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay	[PMID: 37797804]

Chemical Information

CAS No. 2998928-27-9
Molecular Weight 427.50
Formula C₂₆H₂₅N₃O₃
SMILES

COC1=CC(C2=NC3=C(N2)C=CC(C)=C3)=CC=C1OCC(N4CC5=C(C=CC=C5)CC4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Laxmikeshav K, et al. Benzimidazole derivatives as tubulin polymerization inhibitors: Design, synthesis and in vitro cytotoxicity studies. Bioorg Med Chem Lett. 2023 Oct 3;96:129494. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote