2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. Tubulin polymerization-IN-51

Tubulin polymerization-IN-51(compound 7u) is a tubulin polymerization inhibitor with IC50 value of 2.55 - 17.89μM for SK-Mel-28 cells. Tubulin polymerization-IN-51 can be used for cancer research.

For research use only. We do not sell to patients.

Tubulin polymerization-IN-51

Tubulin polymerization-IN-51 Chemical Structure

CAS No. : 2998928-27-9

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Tubulin polymerization-IN-51 Related Antibodies

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Description

Tubulin polymerization-IN-51(compound 7u) is a tubulin polymerization inhibitor with IC50 value of 2.55 - 17.89μM for SK-Mel-28 cells. Tubulin polymerization-IN-51 can be used for cancer research[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
5.5 μM
Compound: 7u
Anticancer activity against human A549 cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay
Anticancer activity against human A549 cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay
[PMID: 37797804]
B16-F10 IC50
4.76 μM
Compound: 7u
Anticancer activity against mouse B16-F10 cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay
Anticancer activity against mouse B16-F10 cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay
[PMID: 37797804]
HCT-116 IC50
6.04 μM
Compound: 7u
Anticancer activity against human HCT-116 cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay
Anticancer activity against human HCT-116 cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay
[PMID: 37797804]
MCF7 IC50
5.9 μM
Compound: 7u
Anticancer activity against human MCF7 cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay
Anticancer activity against human MCF7 cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay
[PMID: 37797804]
NRK-52E IC50
51.85 μM
Compound: 7u
Cytotoxicity against NRK-52E cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay
Cytotoxicity against NRK-52E cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay
[PMID: 37797804]
SK-MEL-28 IC50
2.55 μM
Compound: 7u
Anticancer activity against human SK-MEL-28 cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay
Anticancer activity against human SK-MEL-28 cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay
[PMID: 37797804]
Molecular Weight

427.50

Formula

C26H25N3O3
CAS No.
SMILES

COC1=CC(C2=NC3=C(N2)C=CC(C)=C3)=CC=C1OCC(N4CC5=C(C=CC=C5)CC4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Tubulin polymerization-IN-51 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin polymerization-IN-512998928-27-9Microtubule/TubulinSK-Mel-28 cellscancerInhibitorinhibitorinhibit

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