P-gp inhibitor 20
P-gp inhibitor 20 (compound H27) is a low cytotoxicity P-glycoprotein (P-gp) inhibitor. P-gp inhibitor 20 inhibits the efflux function of P-gp in a dose-dependent manner (without affecting the expression of P-gp), thereby reversing the multidrug resistance (MDR) of MCF-7/ADR cells, with an IC50 value of 46.6 nM. P-gp inhibitor 20 can be used for cancer research.
For research use only. We do not sell to patients.
- CAS No.: 3040917-33-4
- Formula: C30H28N4O3Se
- Molecular Weight:571.53
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NCI/ADR-RES | IC50 |
0.047 μM
Compound: H27
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Reversal of P-gp mediated multidrug resistance in doxorubicin-resistant human MCF-7/ADR cells assessed as doxorubicin IC50 incubated for 48 hrs by CCK-8 assay (Rvb = 12.66 +/- 1.45 microM)
Reversal of P-gp mediated multidrug resistance in doxorubicin-resistant human MCF-7/ADR cells assessed as doxorubicin IC50 incubated for 48 hrs by CCK-8 assay (Rvb = 12.66 +/- 1.45 microM)
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[PMID: 38364715] |
Chemical Information
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CAS No. 3040917-33-4
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Molecular Weight 571.53
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Formula C30H28N4O3Se
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SMILES
O=C(C1=CC=CC([Se]C2=CNC3=CC=C(C4=CN(C)N=C4)C=C32)=C1)N5CCC6=CC(OC)=C(OC)C=C6C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
P-gp inhibitor 20 Related Classifications
HY-161260 Related Classifications
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