521984-48-5
521984-48-5
Chemical Structure
SIS3
- CAS No.: 521984-48-5
- Formula:C28H28ClN3O3
- Molecular Weight:489.99
IUPAC Name: (E)-1-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one hydrochloride
InChIKey: CDKIEBFIMCSCBB-CALJPSDSSA-N
SMILES: [H]Cl.O=C(/C=C/C1=C(N(C2=NC=CC=C21)C)C3=CC=CC=C3)N4CC5=C(CC4)C=C(C(OC)=C5)OC
Biological Activity: SIS3 is a potent and selective inhibitor of Smad3 with an IC50 of 3 μM for Smad3 phosphorylation. SIS3 inhibits the myofibroblast differentiation of fibroblasts by TGF-β1[1].
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SIS3 | 99.62% | SIS3 is a potent and selective inhibitor of Smad3 with an IC50 of 3 μM for Smad3 phosphorylation. SIS3 inhibits the myofibroblast differentiation of fibroblasts by TGF-β1. | ||||||||||||||||||||
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SIS3 (Standard) | ≥98% | SIS3 (Standard) is the analytical standard of SIS3 (HY-13013). This product is intended for research and analytical applications. SIS3 is a potent and selective inhibitor of Smad3 with an IC50 of 3 μM for Smad3 phosphorylation. SIS3 inhibits the myofibroblast differentiation of fibroblasts by TGF-β1. | ||||||||||||||||||||
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