1. Immunology/Inflammation
  2. MyD88
  3. T6167923

T6167923 

Cat. No.: HY-19744
Handling Instructions

T6167923 is a potent and selective inhibitor of MyD88-dependent signaling pathways. T6167923 directly binds to Toll/IL1 receptor (TIR) domain of MyD88 and disrupts MyD88 homodimeric formation. T6167923 inhibits NF-κB driven Staphylococcus enterotoxin AP (SEAP) activity, and improves anti-inflammatory activity with an 50 of 2.7  μM, 2.9 μM, 2.66 μM and 2.66 μM for IFN-γ, IL-1β, IL-6 and TNF-α, respectively.

For research use only. We do not sell to patients.

T6167923 Chemical Structure

T6167923 Chemical Structure

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Description

T6167923 is a potent and selective inhibitor of MyD88-dependent signaling pathways. T6167923 directly binds to Toll/IL1 receptor (TIR) domain of MyD88 and disrupts MyD88 homodimeric formation. T6167923 inhibits NF-κB driven Staphylococcus enterotoxin AP (SEAP) activity, and improves anti-inflammatory activity with an 50 of 2.7  μM, 2.9 μM, 2.66 μM and 2.66 μM for IFN-γ, IL-1β, IL-6 and TNF-α, respectively[1].

IC50 & Target

MyD88[1]

Molecular Weight

458.39

Formula

C₁₇H₂₀BrN₃O₃S₂

SMILES

BrC1=CC(S(=O)(N2CCN(C(N[[email protected]](C3=CC=CS3)C)=O)CC2)=O)=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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T6167923
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HY-19744
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