1. Immunology/Inflammation
  2. MyD88
  3. T6167923

T6167923 

Cat. No.: HY-19744 Purity: 99.42%
Handling Instructions

T6167923 is a potent and selective inhibitor of MyD88-dependent signaling pathways. T6167923 directly binds to Toll/IL1 receptor (TIR) domain of MyD88 and disrupts MyD88 homodimeric formation. T6167923 inhibits NF-κB driven Staphylococcus enterotoxin AP (SEAP) activity, and improves anti-inflammatory activity with an 50 of 2.7  μM, 2.9 μM, 2.66 μM and 2.66 μM for IFN-γ, IL-1β, IL-6 and TNF-α, respectively.

For research use only. We do not sell to patients.

T6167923 Chemical Structure

T6167923 Chemical Structure

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 565 In-stock
Estimated Time of Arrival: December 31
5 mg USD 560 In-stock
Estimated Time of Arrival: December 31
10 mg USD 950 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2500 In-stock
Estimated Time of Arrival: December 31
100 mg USD 4000 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

T6167923 is a potent and selective inhibitor of MyD88-dependent signaling pathways. T6167923 directly binds to Toll/IL1 receptor (TIR) domain of MyD88 and disrupts MyD88 homodimeric formation. T6167923 inhibits NF-κB driven Staphylococcus enterotoxin AP (SEAP) activity, and improves anti-inflammatory activity with an 50 of 2.7  μM, 2.9 μM, 2.66 μM and 2.66 μM for IFN-γ, IL-1β, IL-6 and TNF-α, respectively[1].

IC50 & Target

MyD88[1]

Molecular Weight

458.39

Formula

C₁₇H₂₀BrN₃O₃S₂

SMILES

BrC1=CC(S(=O)(N2CCN(C(N[[email protected]](C3=CC=CS3)C)=O)CC2)=O)=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (545.39 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1815 mL 10.9077 mL 21.8155 mL
5 mM 0.4363 mL 2.1815 mL 4.3631 mL
10 mM 0.2182 mL 1.0908 mL 2.1815 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.54 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.54 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.54 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

T6167923T 6167923T-6167923MyD88Inhibitorinhibitorinhibit

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Product name:
T6167923
Cat. No.:
HY-19744
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