1. Terpenoids and Glycosides
  2. Nootkatone

Nootkatone (Synonyms: (+)-Nootkatone)

Cat. No.: HY-N2195 Purity: 99.35%
Handling Instructions

Nootkatone, a neuroprotective agent from Alpiniae Oxyphyllae Fructus, has antioxidant and anti-inflammatory effects. Nootkatone improves cognitive impairment in lipopolysaccharide-induced mouse model of Alzheimer's disease.

For research use only. We do not sell to patients.

Nootkatone Chemical Structure

Nootkatone Chemical Structure

CAS No. : 4674-50-4

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Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Nootkatone, a neuroprotective agent from Alpiniae Oxyphyllae Fructus, has antioxidant and anti-inflammatory effects[1]. Nootkatone improves cognitive impairment in lipopolysaccharide-induced mouse model of Alzheimer's disease[2].

In Vivo

Nootkatone (10 mg/kg) group shows good performance in behavior experiments including Y-maze test and Morris water maze test. The results of histopathological examination and immunohistochemical analysis showed that LPS induced degeneration of neurons and activation of microglia particularly in hippocampus and Nootkatone (10 mg/kg) reversed these changes. Enzyme linked immunosorbent assay and western blot analysis also demonstrated that the model group had increased expression of IL-1β, IL-6, TNF-α, NLRP3 and NF-κB p65, especially in hippocampus relative to sham-operated group, and Nootkatone (10 mg/kg) decreased the high expression of these inflammatory cytokines[1].

Molecular Weight

218.33

Formula

C₁₅H₂₂O

CAS No.

4674-50-4

SMILES

O=C1C=C2CC[[email protected]@H](C(C)=C)C[[email protected]@]2(C)[[email protected]](C)C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 250 mg/mL (1145.06 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.5802 mL 22.9011 mL 45.8022 mL
5 mM 0.9160 mL 4.5802 mL 9.1604 mL
10 mM 0.4580 mL 2.2901 mL 4.5802 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (9.53 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (9.53 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (9.53 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Nootkatone(+)-NootkatoneOthersneuroprotectivecognitiveimpairmentAlzheimer'sdiseaseInhibitorinhibitorinhibit

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Nootkatone
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HY-N2195
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