2. NF-κB
  3. IKK
  4. PHA 408

PHA 408 (PHA-408) is a potent, selective and orally active IκB kinase-2 (IKK-2) inhibitor. PHA 408 is a powerful anti-inflammatory agent against lipopolysaccharide (LPS)- and cigarette smoke (CS)-mediated lung inflammation.

For research use only. We do not sell to patients.

PHA 408 Chemical Structure

PHA 408 Chemical Structure

CAS No. : 503555-55-3

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5 mg USD 350 In-stock
10 mg USD 600 In-stock
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Based on 1 publication(s) in Google Scholar

PHA 408 Related Antibodies

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IKK-α IKK-β IKK IKKε TBK1

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Description

PHA 408 (PHA-408) is a potent, selective and orally active IκB kinase-2 (IKK-2) inhibitor. PHA 408 is a powerful anti-inflammatory agent against lipopolysaccharide (LPS)- and cigarette smoke (CS)-mediated lung inflammation[1].

IC50 & Target

IKK-2

 

Molecular Weight

560.02

Formula

C29H27ClFN7O2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=NN(C2=CC=C(F)C=C2)C3=C1CCC4=CC=C(NC(C5=C(Cl)C=NC(N6CCN(C)CC6)=C5)=O)C=C43)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 56 mg/mL (100.00 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7857 mL 8.9283 mL 17.8565 mL
5 mM 0.3571 mL 1.7857 mL 3.5713 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (249 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7857 mL 8.9283 mL 17.8565 mL 44.6413 mL
5 mM 0.3571 mL 1.7857 mL 3.5713 mL 8.9283 mL
10 mM 0.1786 mL 0.8928 mL 1.7857 mL 4.4641 mL
15 mM 0.1190 mL 0.5952 mL 1.1904 mL 2.9761 mL
20 mM 0.0893 mL 0.4464 mL 0.8928 mL 2.2321 mL
25 mM 0.0714 mL 0.3571 mL 0.7143 mL 1.7857 mL
30 mM 0.0595 mL 0.2976 mL 0.5952 mL 1.4880 mL
40 mM 0.0446 mL 0.2232 mL 0.4464 mL 1.1160 mL
50 mM 0.0357 mL 0.1786 mL 0.3571 mL 0.8928 mL
60 mM 0.0298 mL 0.1488 mL 0.2976 mL 0.7440 mL
80 mM 0.0223 mL 0.1116 mL 0.2232 mL 0.5580 mL
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PHA 408 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PHA 408503555-55-3PHA408PHA-408IKKIκB kinaseI kappa B kinaseselectiveorally activeanti-inflammatory agentlipopolysaccharidecigarette smokeInhibitorinhibitorinhibit

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