503555-55-3
503555-55-3
Chemical Structure
PHA 408
- CAS No.: 503555-55-3
- Formula:C29H27ClFN7O2
- Molecular Weight:560.02
IUPAC Name: 8-(5-chloro-2-(4-methylpiperazin-1-yl)isonicotinamido)-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide
InChIKey: ZLEZHGHFWIHCGU-UHFFFAOYSA-N
SMILES: O=C(C1=NN(C2=CC=C(F)C=C2)C3=C1CCC4=CC=C(NC(C5=C(Cl)C=NC(N6CCN(C)CC6)=C5)=O)C=C43)N
Biological Activity: PHA 408 (PHA-408) is a potent, selective and orally active IκB kinase-2 (IKK-2) inhibitor. PHA 408 is a powerful anti-inflammatory agent against lipopolysaccharide (LPS)- and cigarette smoke (CS)-mediated lung inflammation[1].
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PHA 408 | 99.40% | PHA 408 (PHA-408) is a potent, selective and orally active IκB kinase-2 (IKK-2) inhibitor. PHA 408 is a powerful anti-inflammatory agent against lipopolysaccharide (LPS)- and cigarette smoke (CS)-mediated lung inflammation. | ||||||||||||||||||||
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References
Keywords
