1. NF-κB
  2. IKK
  3. PF-184

PF-184 

Cat. No.: HY-107591B
Handling Instructions

PF-184 is a potent and selective IKK-2 inhibitor (IC50: 37 nM) over rhIKK-1, IKKi, and more than 30 tyrosine and serine/threonine kinases. PF-184 can be used in the research of inflammation, such as asthma and chronic obstructive pulmonary disease.

For research use only. We do not sell to patients.

PF-184 Chemical Structure

PF-184 Chemical Structure

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Other Forms of PF-184:

Top Publications Citing Use of Products

View All IKK Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PF-184 is a potent and selective IKK-2 inhibitor (IC50: 37 nM) over rhIKK-1, IKKi, and more than 30 tyrosine and serine/threonine kinases. PF-184 can be used in the research of inflammation, such as asthma and chronic obstructive pulmonary disease[1].

IC50 & Target[1]

IKK-2

37 nM (IC50)

In Vitro

PF-184 (0.7 nM-10 μM, 1 h) displays inhibitory activity after successive washes of LPS-stimulated PBMC kinase activation[1].
PF-184 (1 h) broadly inhibits IKK-2-dependent inflammatory products in human disease-relevant cells (such as PBMC, neutrophils, airway epithelial cells, and airway endothelial cells), with IC50 values ranging from 8 nM to 343 nM[1].
PF-184 (2 nM-10 μM, 1 h) inhibits IL-1β-induced TNF-α in a concentration-dependent manner in PBMCs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PF-184 (Intratracheal administration, 0.3-2.5 mg/mL, 100 μL) dose-dependently inhibits neutrophil infiltration and BAL cell cytokine production in rat airway inflammation model[1].
PF-184 (i.v. 2 mg/kg or p.o. 5 mg/kg, rats) shows a T1⁄2 (i.v.) value of 1 h, low oral bioavailability (5%), and high i.v. clearance (59 mL/min/kg)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat airway model of neutrophilia[1]
Dosage: 0.3-2.5 mg/mL, 100 μL
Administration: Intratracheal administration
Result: Suppressed neutrophil infiltration with an EC50 value of 1 mg/mL.
Suppressed BAL fluid TNF-α and PGE2 levels, and inhibited p65 translocation.
Molecular Weight

619.09

Formula

C32H32ClFN6O4

SMILES

O=C(C1=NN(C2=C1CCC3=C2C=C(NC(C4=CC(N5C[[email protected]](CO)([[email protected]](CO)(C5)C)C)=NC=C4Cl)=O)C=C3)C6=CC=C(C=C6)F)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
PF-184
Cat. No.:
HY-107591B
Quantity:
MCE Japan Authorized Agent: