1. Immunology/Inflammation
    Metabolic Enzyme/Protease
  2. FLAP
    Epoxide Hydrolase
  3. Diflapolin

Diflapolin 

Cat. No.: HY-128171
Handling Instructions

Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity. Diflapolin inhibits 5-LOX product formation in intact human monocytes and neutrophils with IC50s of  30 and 170 nM, respectively, and suppressed the activity of isolated sEH (IC50=20 nM).

For research use only. We do not sell to patients.

Diflapolin Chemical Structure

Diflapolin Chemical Structure

CAS No. : 724453-98-9

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Description

Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity. Diflapolin inhibits 5-LOX product formation in intact human monocytes and neutrophils with IC50s of  30 and 170 nM, respectively, and suppressed the activity of isolated sEH (IC50=20 nM)[1].

In Vivo

Diflapolin (1-10 mg/kg; i.p.; 30 min before zymosan injection) exhibits potent anti-inflammatory properties in in-vivo experiments[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male CD-1 mice (zymosan-induced peritonitis mouse model)[1]
Dosage: 1, 3 and 10 mg/kg
Administration: I.p.; 30 min before zymosan injection
Result: Induced a significant reduction of LTC4 and LTB4 peritoneal levels, starting from the dose of 1 mg/kg and comparable to the effect of MK886.
Molecular Weight

458.36

Formula

C₂₂H₁₇Cl₂N₃O₂S

CAS No.

724453-98-9

SMILES

O=C(NC1=CC=C(Cl)C(Cl)=C1)NC2=CC=C(OCC3=NC4=CC=CC=C4S3)C=C2C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

DiflapolinFLAPEpoxide Hydrolase5-lipoxygenase-activating protein5-LO activating proteinvascularpermeabilitycysteinyl-LTsneutrophilinfiltrationinflammationdiseasesInhibitorinhibitorinhibit

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Diflapolin
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HY-128171
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