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  2. FLAP
  3. AM679

AM679 

Cat. No.: HY-14460 Purity: 99.72%
Handling Instructions

AM679 is a potent, selective 5-lipoxygenase-activating protein (FLAP) inhibitor with an IC50 of 2 nM in a human FLAP membrane binding assay. AM679 markedly reduces the respiratory syncytial virus-driven ocular pathology as well as the synthesis of cysteinyl leukotrienes (CysLTs) in the eye.

For research use only. We do not sell to patients.

AM679 Chemical Structure

AM679 Chemical Structure

CAS No. : 1206880-66-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 476 In-stock
Estimated Time of Arrival: December 31
5 mg USD 312 In-stock
Estimated Time of Arrival: December 31
10 mg USD 403 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1087 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1680 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

AM679 is a potent, selective 5-lipoxygenase-activating protein (FLAP) inhibitor with an IC50 of 2 nM in a human FLAP membrane binding assay. AM679 markedly reduces the respiratory syncytial virus-driven ocular pathology as well as the synthesis of cysteinyl leukotrienes (CysLTs) in the eye[1].

In Vitro

AM679 is a potent, selective inhibitor of FLAP, as demonstrated in an in vitro human FLAP membrane binding assay with IC50 of 2 nM and when assayed as an inhibitor of ex vivo ionophore-challenged mouse and human blood LTB4 synthesis with IC50s of 55 nM and 154 nM, respectively[1].
AM679 is a potent and selective FLAP inhibitor with IC50s of 2.2 nM/0.6 nM/154 nM for FLAP binding/hLA/hWB respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AM679 shows potent inhibition of leukotrienes in human blood and in a rodent bronchoalvelolar lavage challenge model[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

692.87

Formula

C₄₀H₄₄N₄O₅S

CAS No.
SMILES

O=C(C)N1C2=CC=CC=C2C[[email protected]]1COC3=CC=C(N(CC4=CC=C(C5=NC=C(OC)C=N5)C=C4)C(CC(C)(C(O)=O)C)=C6SC(C)(C)C)C6=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (144.33 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4433 mL 7.2164 mL 14.4327 mL
5 mM 0.2887 mL 1.4433 mL 2.8865 mL
10 mM 0.1443 mL 0.7216 mL 1.4433 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.75 mg/mL (3.97 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.75 mg/mL (3.97 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.72%

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Keywords:

AM679AM 679AM-679FLAP5-lipoxygenase-activating protein5-LO activating proteinInhibitorinhibitorinhibit

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AM679
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HY-14460
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