1. Immunology/Inflammation
  2. FLAP
  3. AM679

AM679 

Cat. No.: HY-14460 Purity: 99.98%
Handling Instructions

AM679 is a potent and selective FLAP inhibitor with IC50s of 2.2 nM/0.6 nM/154 nM for FLAP binding/hLA/hWB respectively.

For research use only. We do not sell to patients.

AM679 Chemical Structure

AM679 Chemical Structure

CAS No. : 1206880-66-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 476 In-stock
Estimated Time of Arrival: December 31
5 mg USD 312 In-stock
Estimated Time of Arrival: December 31
10 mg USD 403 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1087 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1680 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

AM679 is a potent and selective FLAP inhibitor with IC50s of 2.2 nM/0.6 nM/154 nM for FLAP binding/hLA/hWB respectively. IC50 value: 2.2 nM/0.6 nM/154 nM(FLAP binding/hLA/hWB) [1] Target: FLAP in vitro: AM679 showed excellent in vitro inhibition against FLAP. AM679 has an excellent hWB IC50 potency of 154 nM. AM679 showed an improved CYP inhibition profile (IC50 3A4 = 16.7 lM, 2C9 = 3.7 lM, 2D6 >30 lM), no time dependent inhibition against CYP3A4 (0.003 min-1 vs 0.057 min-1 for troleandomycin control 10 uM) and no CYP3A4 induction. in vivo: AM679 was profiled in a rodent bronchoalveolar lavage (BAL) model to measure its ability to inhibit production of leukotrienes in vivo.16 Oral administration of 39 (10 mg/kg as the sodium carboxylate salt) 4 h prior to ionophore challenge reduced LTB4 and CysLT levels in the rodent lung lavage fluid by 98% and 87%, respectively, with corresponding average rodent plasma levels of 605 nM (3 h post dose, rat blood LTB4 IC50 = 125 nM).

Molecular Weight

692.87

Formula

C₄₀H₄₄N₄O₅S

CAS No.

1206880-66-1

SMILES

O=C(C)N1C2=CC=CC=C2C[[email protected]]1COC3=CC=C(N(CC4=CC=C(C5=NC=C(OC)C=N5)C=C4)C(CC(C)(C(O)=O)C)=C6SC(C)(C)C)C6=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (144.33 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4433 mL 7.2164 mL 14.4327 mL
5 mM 0.2887 mL 1.4433 mL 2.8865 mL
10 mM 0.1443 mL 0.7216 mL 1.4433 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.75 mg/mL (3.97 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.75 mg/mL (3.97 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

AM679AM 679AM-679FLAP5-lipoxygenase-activating protein5-LO activating proteinInhibitorinhibitorinhibit

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AM679
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HY-14460
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