1. Metabolic Enzyme/Protease
  2. Epoxide Hydrolase
  3. AR-9281

AR-9281 (Synonyms: APAU)

Cat. No.: HY-111151 Purity: 98.12%
Handling Instructions

AR9281 is a potent and selective inhibitor of soluble epoxide hydrolase (s-EH), with potential for the treatment of hypertension and type 2 diabetes.

For research use only. We do not sell to patients.

AR-9281 Chemical Structure

AR-9281 Chemical Structure

CAS No. : 913548-29-5

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 154 In-stock
Estimated Time of Arrival: December 31
5 mg USD 140 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

AR9281 is a potent and selective inhibitor of soluble epoxide hydrolase (s-EH), with potential for the treatment of hypertension and type 2 diabetes[1].

IC50 & Target

s-EH[1]

Molecular Weight

319.44

Formula

C₁₈H₂₉N₃O₂

CAS No.

913548-29-5

SMILES

O=C(NC1(C2)CC3CC2CC(C3)C1)NC4CCN(C(C)=O)CC4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (78.26 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1305 mL 15.6524 mL 31.3048 mL
5 mM 0.6261 mL 3.1305 mL 6.2610 mL
10 mM 0.3130 mL 1.5652 mL 3.1305 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.51 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (6.51 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.51 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.12%

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

AR-9281APAUAR9281AR 9281Epoxide HydrolaseInhibitorinhibitorinhibit

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Product Name:
AR-9281
Cat. No.:
HY-111151
Quantity:
MCE Japan Authorized Agent: