913548-29-5
913548-29-5
Chemical Structure
AR-9281
Synonym(s): APAU
- CAS. Nr.: 913548-29-5
- Formula:C18H29N3O2
- Molecular Weight:319.44
IUPAC Name: 1-(1-acetylpiperidin-4-yl)-3-(adamantan-1-yl)urea
InChIKey: HUDQLWBKJOMXSZ-UHFFFAOYSA-N
SMILES: O=C(NC1(C2)CC3CC2CC(C3)C1)NC4CCN(C(C)=O)CC4
Biological Activity: AR9281 (APAU) is a potent, selective and orally active soluble epoxide hydrolase (s-EH) inhibitor. AR-9281 can inhibits human sEH (HsEH) and murine sEH (MsEH) with IC50 values of 13.8 nM and 1.7 nM, respectively. AR9281 can be used for the research of inflammation, hypertension and type 2 diabetes[1][2].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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AR-9281 | 99.69% | AR9281 (APAU) is a potent, selective and orally active soluble epoxide hydrolase (s-EH) inhibitor. AR-9281 can inhibits human sEH (HsEH) and murine sEH (MsEH) with IC50 values of 13.8 nM and 1.7 nM, respectively. AR9281 can be used for the research of inflammation, hypertension and type 2 diabetes. | ||||||||||||||||||||
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AR-9281 (Standard) | ≥98% | AR-9281 (Standard) is the analytical standard of AR-9281. This product is intended for research and analytical applications. AR9281 (APAU) is a potent, selective and orally active soluble epoxide hydrolase (s-EH) inhibitor. AR-9281 can inhibits human sEH (HsEH) and murine sEH (MsEH) with IC50 values of 13.8 nM and 1.7 nM, respectively. AR9281 can be used for the research of inflammation, hypertension and type 2 diabetes. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.66
HY-138573N-Acetyl Adamantamine -
Similarity Score 0.61
HY-1147471-(Adamantan-1-yl)-3-propylthiourea -
Similarity Score 0.61
HY-W3388561-Adamantylthiourea -
Similarity Score 0.61
HY-108570AUDA -
Similarity Score 0.61
HY-138573SN-Acetyl Adamantamine-d3 -
Similarity Score 0.60
HY-1679191-(1-Adamantyl)-3-butyl-2-thiourea -
Similarity Score 0.60
HY-U00124BTromantadine hydrochloride -
Similarity Score 0.60
HY-U00124Tromantadine -
Similarity Score 0.54
HY-139424SQ609 -
Explore the MedChemAI to find more analogs
References
- [1]. Fangyu Du, et al. Discovery of memantyl urea derivatives as potent soluble epoxide hydrolase inhibitors against lipopolysaccharide-induced sepsis. Eur J Med Chem. 2021 Nov 5;223:113678. [Content Brief]
- [2]. Kathleen Guglielmino, et al. Pharmacological inhibition of soluble epoxide hydrolase provides cardioprotection in hyperglycemic rats. Am J Physiol Heart Circ Physiol. 2012 Oct 1;303(7):H853-62. [Content Brief]
