1. Anti-infection
  2. Bacterial
  3. SQ609

SQ609 

Cat. No.: HY-139424
Handling Instructions

SQ609 is a lead compound from a library of dipiperidines. SQ609 inhibits more than 90% of intracellular bacterial growth at 4μg/ml and is toxic to these cells. SQ609 displays a potent antitubercular activity .

For research use only. We do not sell to patients.

SQ609 Chemical Structure

SQ609 Chemical Structure

CAS No. : 627052-25-9

Size Price Stock Quantity
25 mg USD 400 In-stock
Estimated Time of Arrival: December 31
50 mg USD 680 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

SQ609 is a lead compound from a library of dipiperidines. SQ609 inhibits more than 90% of intracellular bacterial growth at 4μg/ml and is toxic to these cells. SQ609 displays a potent antitubercular activity [1].

In Vitro

In Mtb-infected macrophages in vitro, SQ609 inhibits more than 90% of intracellular bacterial growth at 4μg/ml and is toxic to these cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SQ609 (10 mg/kg; intravenous injection) completely prevents weight loss in the Mtb-infected animals and prolongs the therapeutic effect following drug withdrawal for another 10-15 days[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: TB susceptible mice (C3H/He)[1]
Dosage: 10 mg/kg
Administration: I.v.
Result: Prevented weight loss in the Mtb-infected animals and prolonged the therapeutic effect following drug withdrawal for another 10-15 days.
Molecular Weight

346.55

Formula

C₂₂H₃₈N₂O

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 6.67 mg/mL (19.25 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8856 mL 14.4279 mL 28.8559 mL
5 mM 0.5771 mL 2.8856 mL 5.7712 mL
10 mM 0.2886 mL 1.4428 mL 2.8856 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 0.67 mg/mL (1.93 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.67 mg/mL (1.93 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
SQ609
Cat. No.:
HY-139424
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