724453-98-9
Chemical Structure
Diflapolin
- CAS No.: 724453-98-9
- Formula:C22H17Cl2N3O2S
- Molecular Weight:458.36
IUPAC Name: 1-(4-(benzo[d]thiazol-2-ylmethoxy)-2-methylphenyl)-3-(3,4-dichlorophenyl)urea
InChIKey: FGXLEECGXSDIMM-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(Cl)C(Cl)=C1)NC2=CC=C(OCC3=NC4=CC=CC=C4S3)C=C2C
Biological Activity: Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity. Diflapolin inhibits 5-LOX product formation in intact human monocytes and neutrophils with IC50s?of? 30 and 170?nM, respectively, and suppressed the activity of isolated sEH (IC50=20?nM)[1].
| Cat. No. | Nom du produit | Pureté | Description | Pricing | |||||||||||||||||||
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Diflapolin | 99.33% | Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity. Diflapolin inhibits 5-LOX product formation in intact human monocytes and neutrophils with IC50s?of? 30 and 170?nM, respectively, and suppressed the activity of isolated sEH (IC50=20?nM). | ||||||||||||||||||||
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