1. Immunology/Inflammation
  2. FLAP

MK-886 (Synonyms: L 663536)

Cat. No.: HY-14166 Purity: 99.70%
Handling Instructions

MK886 is a potent 5-lipoxygenase activating protein inhibitor (FLAP) also a non-competitive inhibitor of PPAR alpha. a potent inhibitor of leukotriene (LT) biosynthesis in intact human polymorphonuclear leukocytes with IC 50 of 2.5 nM. Block the synthessis of leukotrien intact activate leukocyte.

For research use only. We do not sell to patients.

MK-886 Chemical Structure

MK-886 Chemical Structure

CAS No. : 118414-82-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 92 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
5 mg USD 84 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 144 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
25 mg USD 288 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
50 mg USD 528 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
100 mg USD 756 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

MK886 is a potent 5-lipoxygenase activating protein inhibitor (FLAP) also a non-competitive inhibitor of PPAR alpha. a potent inhibitor of leukotriene (LT) biosynthesis in intact human polymorphonuclear leukocytes with IC 50 of 2.5 nM. Block the synthessis of leukotrien intact activate leukocyte. target: FLAP, LT IC50: 2.5 nM ( leukotriene ,LT ) In vitro: MK886 inhibit PPAR alpha by a non-competitive mechanism as shown by its effects on the binding of arachidonic acid to PPAR alpha protein. The expression of keratin-1 is reduced by MK886 in a culture of mouse primary keratinocytes. MK886 functioning as a non-competitive inhibitor of PPAR alpha, but may also indicate that PPAR alpha is not directly involved in MK886-induced apoptosis. In vivo: L-663,536 inhibit A23187-induced LTB4 formation by rat peripheral blood and elicited PMN. The compound inhibited leukotriene biosynthesis in vivo in a rat pleurisy model (ED50, 0.2 mg/kg p.o.), an inflamed rat paw model (ED50, 0.8 mg/kg)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 32 mg/mL (67.79 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1183 mL 10.5914 mL 21.1828 mL
5 mM 0.4237 mL 2.1183 mL 4.2366 mL
10 mM 0.2118 mL 1.0591 mL 2.1183 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

472.08

Formula

C₂₇H₃₄ClNO₂S

CAS No.

118414-82-7

SMILES

CC(C)C1=CC=C(N(CC2=CC=C(Cl)C=C2)C(CC(C)(C(O)=O)C)=C3SC(C)(C)C)C3=C1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
MK-886
Cat. No.:
HY-14166
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MK-886

Cat. No.: HY-14166