1. Immunology/Inflammation
  2. FLAP
  3. MK-886

MK-886 (Synonyms: L 663536)

Cat. No.: HY-14166 Purity: 99.77%
Handling Instructions

MK-886 (L 663536) is a 5-lipoxygenase-activating protein inhibitor and a leukotriene biosynthesis inhibitor (IC50=2.5 nM).

For research use only. We do not sell to patients.

MK-886 Chemical Structure

MK-886 Chemical Structure

CAS No. : 118414-82-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 92 In-stock
Estimated Time of Arrival: December 31
5 mg USD 84 In-stock
Estimated Time of Arrival: December 31
10 mg USD 144 In-stock
Estimated Time of Arrival: December 31
25 mg USD 288 In-stock
Estimated Time of Arrival: December 31
50 mg USD 528 In-stock
Estimated Time of Arrival: December 31
100 mg USD 756 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 4 publication(s) in Google Scholar

Top Publications Citing Use of Products

    MK-886 purchased from MCE. Usage Cited in: J Pediatr Surg. 2019 Feb.

    Immunocytochemical staining shows the morphology of cytoskeleton in SH-SY5Y and SK-N-BE2 cells. The morphology and function of cytoskeleton are observed in confocal images and the fluorescence intensity of the cytoskeleton in the PGE2 group is weakened and led to morphological changes and broke the cytoskeleton. The PTGES inhibitor MK886 can reverse the changes caused by PGE2.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    MK-886 (L 663536) is a 5-lipoxygenase-activating protein inhibitor and a leukotriene biosynthesis inhibitor (IC50=2.5 nM).

    Molecular Weight

    472.08

    Formula

    C₂₇H₃₄ClNO₂S

    CAS No.

    118414-82-7

    SMILES

    CC(C)C1=CC=C(N(CC2=CC=C(Cl)C=C2)C(CC(C)(C(O)=O)C)=C3SC(C)(C)C)C3=C1

    Shipping

    Room temperature in continental US; may vary elsewhere

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 32 mg/mL (67.79 mM)

    H2O : < 0.1 mg/mL (insoluble)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.1183 mL 10.5914 mL 21.1828 mL
    5 mM 0.4237 mL 2.1183 mL 4.2366 mL
    10 mM 0.2118 mL 1.0591 mL 2.1183 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (5.30 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 99.77%

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    Product Name:
    MK-886
    Cat. No.:
    HY-14166
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