118414-82-7
Chemical Structure
MK-886
Synonym(s): L 663536
- CAS No.: 118414-82-7
- Formula:C27H34ClNO2S
- Molecular Weight:472.08
IUPAC Name: 3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl)-2,2-dimethylpropanoic acid
InChIKey: QAOAOVKBIIKRNL-UHFFFAOYSA-N
SMILES: CC(C)C1=CC=C(N(CC2=CC=C(Cl)C=C2)C(CC(C)(C(O)=O)C)=C3SC(C)(C)C)C3=C1
Biological Activity: MK-886 (L 663536) is a potent, cell-permeable and orally active FLAP (IC50 of 30 nM) and leukotriene biosynthesis (IC50s of 3 nM and 1.1 μM in intact leukocytes and human whole blood, respectively) inhibitor. MK-886 is also a non-competitive PPARα antagonist and can induce apoptosis[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MK-886 | 99.77% | MK-886 (L 663536) is a potent, cell-permeable and orally active FLAP (IC50 of 30 nM) and leukotriene biosynthesis (IC50s of 3 nM and 1.1 μM in intact leukocytes and human whole blood, respectively) inhibitor. MK-886 is also a non-competitive PPARα antagonist and can induce apoptosis. | ||||||||||||||||||||
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MK-886 (Standard) | ≥98% | MK-886 (Standard) is the analytical standard of MK-886. This product is intended for research and analytical applications. MK-886 (L 663536) is a potent, cell-permeable and orally active FLAP (IC50 of 30 nM) and leukotriene biosynthesis (IC50s of 3 nM and 1.1 μM in intact leukocytes and human whole blood, respectively) inhibitor. MK-886 is also a non-competitive PPARα antagonist and can induce apoptosis. | ||||||||||||||||||||
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Similarity Score 0.91
HY-14166AMK-886 sodium salt -
Similarity Score 0.67
HY-10037RQuiflapon (Standard) -
Similarity Score 0.64
HY-108564L 655240 -
Similarity Score 0.63
HY-50714RQuiflapon sodium (Standard) -
Similarity Score 0.59
HY-125089AM-643 -
Similarity Score 0.59
HY-14162AM103 free acid -
Similarity Score 0.58
HY-15874Fiboflapon -
Similarity Score 0.55
HY-14163AM103 -
Similarity Score 0.55
HY-118197L-669083 -
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References
- [1]. Kehrer JP et al. Inhibition of peroxisome-proliferator-activated receptor (PPAR)alpha by MK886. Biochem J. 2001 Jun 15. [Content Brief]
- [2]. Gillard J et al. L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor. Can J Physiol Pharmacol. 1989 May;67(5):456-64. [Content Brief]
