MK-886 sodium salt
Based on 14 publication(s) in Google Scholar
MK-886 (L 663536) sodium salt is a potent, cell-permeable and orally active FLAP (IC50 of 30 nM) and leukotriene biosynthesis (IC50s of 3 nM and 1.1 μM in intact leukocytes and human whole blood, respectively) inhibitor. MK-886 sodium salt is also a non-competitive PPARα antagonist and can induce apoptosis.
For research use only. We do not sell to patients.
- CAS No.: 118427-55-7
- Formula: C27H33ClNNaO2S
- Molecular Weight:494.06
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Publications Citing Use of MedChemExpress (MCE) MK-886 sodium salt
More- Cell Host Microbe. 2026 Jul 8;34(7):1350-1366.e8. [Abstract]
- Redox Biol. 2023 Jun:62:102706. [Abstract]
- J Exp Clin Cancer Res. 2025 Jul 4;44(1):192. [Abstract]
- J Transl Med. 2025 Jul 25;23(1):833. [Abstract]
- Mol Med. 2025 Apr 24;31(1):153. [Abstract]
- Genes Dev. 2023 Mar 1;37(5-6):204-217. [Abstract]
- Chem Biol Interact. 2019 Feb 25:300:123-130. [Abstract]
- J Mol Med (Berl). 2025 Aug 19. [Abstract]
- iScience. 2026 Jan 29;29(2):114839. [Abstract]
- Hum Exp Toxicol. 2021 Jul;40(7):1208-1221. [Abstract]
- J Immunol Res. 2022 May 20;2022:4086710. [Abstract]
- J Pediatr Surg. 2019 Oct;54(10):2032-2037. [Abstract]
- Patent. US20240299347A1.
- Research Square Preprint. 2021 Feb.
Customer Validation & Images
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Bio/Physico-chemical Assay
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Cell Migration/Invasion Assay
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In Vivo Efficacy Study
All Leukotriene Receptor Isoforms
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Biological Activity
IC50: 30 nM (FLAP)[3]
IC50: 3 nM (Leukotriene biosynthesis in intact leukocytes) and 1.1 μM (Leukotriene biosynthesis in human whole blood)[2]
PPARα[1]
MK-886 sodium salt (0.5-2 μM; 15?hours; primary keratinocytes) treatment reduces keratin-1 expression in a culture of mouse primary keratinocytes[1].
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Using a transient transfection system in monkey kidney fibroblast CV-1 cells, mouse keratinocyte 308 cells and human lung adenocarcinoma A549 cells, 10 μM MK-886 sodium salt is able to inhibit Wy-14643 activation of PPARα by ~80%. MK-886 sodium salt also decreases PPARα activation by fatty acids in the stable transfection system[1].
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Although Jurkat cells express all PPAR isoforms, various PPARα and PPARγ agonists are unable to prevent MK-886 sodium salt-induced apoptosis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
? MK-886 sodium salt (L 663536) inhibits leukotriene biosynthesis in vivo in a rat pleurisy model (ED50, 0.2 mg/kg p.o.), an inflamed rat paw model (ED50, 0.8 mg/kg), a model of leukotriene excretion in rat bile following antigen provocation[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 118427-55-7
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Molecular Weight 494.06
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Formula C27H33ClNNaO2S
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SMILES
O=C(C(C)(CC1=C(C2=C(N1CC3=CC=C(C=C3)Cl)C=CC(C(C)C)=C2)SC(C)(C)C)C)O[Na]
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Synonyms
L 663536 sodium salt
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (14)
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Journal Impact Factor
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Most Recent
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Cell Host Microbe
Gut bacteria that produce fatty acid ethanolamides alleviate diarrhea-predominant IBS with insulin resistance. [Abstract]2026 Jul 8;34(7):1350-1366.e8. PMID: 42320473 -
Redox Biol
MK-886 protects against cardiac ischaemia/reperfusion injury by activating proteasome-Keap1-NRF2 signalling. [Abstract]2023 Jun:62:102706. PMID: 37098317
MK-886 sodium salt purchased from MedChemExpress. Usage Cited in: Redox Biol. 2023 Jun:62:102706. [Abstract]
Male mice were pretreated with MK-886 (20 mg/kg) and epoxomicin (Epox, 1 mg/kg) at 2 and 24 h before I/R-mediated cardiac injury. Echocardiographic images of the left ventricle (left). Scale bar: 0.2 s. Quantification of EF% and FS% (right, n = 6).
MK-886 sodium salt purchased from MedChemExpress. Usage Cited in: Redox Biol. 2023 Jun:62:102706. [Abstract]
Male mice were pretreated with MK-886 (20 mg/kg) and epoxomicin (Epox, 1 mg/kg) at 2 and 24 h before I/R-mediated cardiac injury. Images of Evans blue and TTC staining (left) for infarct size analysis, with quantification of the infarction area/left ventricular (LV) area and area at risk (AAR)/LV area ratios (right; n = 6).
MK-886 sodium salt purchased from MedChemExpress. Usage Cited in: Redox Biol. 2023 Jun:62:102706. [Abstract]
Male mice were pretreated with MK-886 (20 mg/kg) and epoxomicin (Epox, 1 mg/kg) at 2 and 24 h before I/R-mediated cardiac injury. Images of TUNEL (red), α-actinin (green), and DAPI (blue) staining of cardiac slices (left) and the percentage of TUNEL+ nuclei (right; n = 6).
MK-886 sodium salt purchased from MedChemExpress. Usage Cited in: Redox Biol. 2023 Jun:62:102706. [Abstract]
Male mice were pretreated with MK-886 (20 mg/kg) and epoxomicin (Epox, 1 mg/kg) at 2 and 24 h before I/R-mediated cardiac injury. qPCR analysis of Bax and Bcl-2 mRNA levels in the border zone of the ischemic heart (n = 6) and quantification of the relative Bax/Bcl-2 ratio.
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J Exp Clin Cancer Res
Adipocytes-induced ANGPTL4/KLF4 axis drives glycolysis and metastasis in triple-negative breast cancer. [Abstract]2025 Jul 4;44(1):192. PMID: 40616161
MK-886 sodium salt purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2025 Jul 4;44(1):192. [Abstract]
Western blot analysis of PPARα and ANGPTL4 protein expression in TNBC cell lines stimulated with PA and or treated with the PPARα inhibitor MK-886 (5 µM).
MK-886 sodium salt purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2025 Jul 4;44(1):192. [Abstract]
Western blot analysis of PPARα, ANGPTL4, HK2, PFKP, PGK1, PGAM1, LDHA in TNBC cells cocultured with adipocytes, or treated with MK-886 (5 µM) in a co-culture system.
MK-886 sodium salt purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2025 Jul 4;44(1):192. [Abstract]
The OCR and ECAR levels of TNBC cells in each group were measured in TNBC cells cultured alone, co-cultured with adipocytes, or treatment of MK-886(5µM) in the co-culture system.
MK-886 sodium salt purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2025 Jul 4;44(1):192. [Abstract]
Transwell assay to measure the role of MK-886 treatment on the migration ability of TNBC cells induced by adipocytes.
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J Transl Med
KAT2B regulates estradiol synthesis via H3K27ac/PPARα in granulosa cells of PCOS patients. [Abstract]2025 Jul 25;23(1):833. PMID: 40713779 -
Mol Med
Formononetin ameliorates depression-like behaviors through rebalancing microglia M1/M2 polarization and inhibiting NLRP3 inflammasome: involvement of activating PPARα-mediated autophagy. [Abstract]2025 Apr 24;31(1):153. PMID: 40275171 -
Genes Dev
ALOX5-mediated ferroptosis acts as a distinct cell death pathway upon oxidative stress in Huntington's disease. [Abstract]2023 Mar 1;37(5-6):204-217. PMID: 36921996 -
Chem Biol Interact
Taurine protected As2O3-induced the activation of hepatic stellate cells through inhibiting PPARα-autophagy pathway. [Abstract]2019 Feb 25:300:123-130. PMID: 30677399 -
J Mol Med (Berl)
4-Hydroxychalcone alleviated Angiotensin II-induced atrial fibrillation via immunoproteasome-IKK-NF-κB signaling pathway modulation. [Abstract]2025 Aug 19. PMID: 40828375 -
iScience
Targeted inhibition of M2 macrophages polarization via a PDC attenuates chronic pancreatitis through the PPARα pathway. [Abstract]2026 Jan 29;29(2):114839. PMID: 41716994 -
Hum Exp Toxicol
2021 Jul;40(7):1208-1221. PMID: 33538198 -
J Immunol Res
Respiratory Syncytial Virus Nonstructural Protein 1 Promotes 5-Lipoxygenase via miR-19a-3p. [Abstract]2022 May 20;2022:4086710. PMID: 35637792 -
J Pediatr Surg
MPGES-1 derived PGE2 inhibits cell migration by regulating ARP2/3 in the pathogenesis of Hirschsprung disease. [Abstract]2019 Oct;54(10):2032-2037. PMID: 30814036 -
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Purity & Documentation
References
[1]. Kehrer JP et al. Inhibition of peroxisome-proliferator-activated receptor (PPAR)alpha by MK886. Biochem J. 2001 Jun 15. [Content Brief]
[2]. Gillard J et al. L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor. Can J Physiol Pharmacol. 1989 May;67(5):456-64. [Content Brief]
[3]. Mancini JA, et al. 5-Lipoxygenase-activating protein is the target of a novel hybrid of two classes of leukotriene biosynthesis inhibitors. Mol Pharmacol. 1992 Feb;41(2):267-72. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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