Terminolic acid
Based on 1 Customer Validation
Terminolic acid is a pentacyclic triterpene glycoside and antibacterial agent. Terminolic acid can be isolated from Combretum racemosum. Terminolic acid inhibits proinflammatory cytokines by binding to the receptor active sites of IL-1β and IL-6. Terminolic acid reduces IL-8. Terminolic acid has antibacterial activity against Staphylococcus aureus, Escherichia coli and Enterococcus faecalis with MICs ranging from 64 to 256 μg/mL. Terminolic acid is used in colon cancer research.
For research use only. We do not sell to patients.
- Purity: 99.92%
- CAS No.: 564-13-6
- Formula: C30H48O6
- Molecular Weight:504.70
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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IL-8 |
IL-6 |
IL-1β |
Terminolic acid shows moderate antibacterial activity against Staphylococcus aureus, Escherichia coli and Enterococcus faecalis with MICs ranging from 64 to 256 μg/mL[1].
Terminolic acid (63.9 μM) reduces the production of IL-8 to 35% in human colon cancer cells HT-29[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 564-13-6
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Appearance Solid
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Molecular Weight 504.70
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Formula C30H48O6
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Color White to off-white
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SMILES
C[C@@]1(C[C@H]2O)[C@@](CC=C([C@]3([H])CC4(C)C)[C@]1(CC[C@]3(CC4)C(O)=O)C)([H])[C@]([C@]2([H])[C@@](C)([C@H]5O)CO)(C[C@H]5O)C
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 100 mg/mL (198.14 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Gossan DPA, et, al. Antibacterial and cytotoxic triterpenoids from the roots of Combretum racemosum. Fitoterapia. 2016 Apr;110:89-95. [Content Brief]
[3]. Yang GX, et al. Chemical constituents from Melastoma dodecandrum and their inhibitory activity on interleukin-8 production in HT-29 cells. Nat Prod Res. 2014;28(17):1383-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9814 mL | 9.9069 mL | 19.8138 mL | 49.5344 mL |
| 5 mM | 0.3963 mL | 1.9814 mL | 3.9628 mL | 9.9069 mL | |
| 10 mM | 0.1981 mL | 0.9907 mL | 1.9814 mL | 4.9534 mL | |
| 15 mM | 0.1321 mL | 0.6605 mL | 1.3209 mL | 3.3023 mL | |
| 20 mM | 0.0991 mL | 0.4953 mL | 0.9907 mL | 2.4767 mL | |
| 25 mM | 0.0793 mL | 0.3963 mL | 0.7926 mL | 1.9814 mL | |
| 30 mM | 0.0660 mL | 0.3302 mL | 0.6605 mL | 1.6511 mL | |
| 40 mM | 0.0495 mL | 0.2477 mL | 0.4953 mL | 1.2384 mL | |
| 50 mM | 0.0396 mL | 0.1981 mL | 0.3963 mL | 0.9907 mL | |
| 60 mM | 0.0330 mL | 0.1651 mL | 0.3302 mL | 0.8256 mL | |
| 80 mM | 0.0248 mL | 0.1238 mL | 0.2477 mL | 0.6192 mL | |
| 100 mM | 0.0198 mL | 0.0991 mL | 0.1981 mL | 0.4953 mL |
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