1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. nAChR

GTS-21 dihydrochloride (Synonyms: DMXB-A; DMBX-anabaseine)

Cat. No.: HY-14564A Purity: 99.76%
Handling Instructions

GTS-21 dihydrochloride is a selective α7 nicotinic acetylcholine receptor agonist, has recently been established as a promising treatment for inflammation.

For research use only. We do not sell to patients.

GTS-21 dihydrochloride Chemical Structure

GTS-21 dihydrochloride Chemical Structure

CAS No. : 156223-05-1

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 96 In-stock
Estimated Time of Arrival: December 31
50 mg USD 384 In-stock
Estimated Time of Arrival: December 31
100 mg USD 660 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

GTS-21 dihydrochloride is a selective α7 nicotinic acetylcholine receptor agonist, has recently been established as a promising treatment for inflammation. Target: nAChR in vitro: GTS-21 is one of the most potent α7nAChR agonists, has been reported to attenuate pro-inflammatory cytokine production, improve outcomes in sepsis models, pancreatitis, and ischemia-reperfusion injury, and inhibit the production of endotoxin-induced TNF in lung tissue. In addition, recent studies have demonstrated that GTS-21 inhibits the activities of endothelial cells and monocyte macrophages, as well as the secretion of pro-inflammatory cytokines in peripheral blood samples, by regulating the JAK2-STAT3 pathway. [1] in vivo: In septic animals, GTS-21 significantly ameliorated GI motility, lowered systemic and colonic levels of IL-6, decreased colonic permeability, and decreased the number of positive cultures obtained from blood and mesenteric lymph nodes. Splenectomy prevented animals from developing sepsis-induced ileus. Chrna7 mice displayed a more severe septic phenotype, whereas GTS-21 remarkably was also beneficial in these animals. [2]

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : 16.5 mg/mL (43.27 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6226 mL 13.1130 mL 26.2261 mL
5 mM 0.5245 mL 2.6226 mL 5.2452 mL
10 mM 0.2623 mL 1.3113 mL 2.6226 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

381.30

Formula

C₁₉H₂₂Cl₂N₂O₂

CAS No.

156223-05-1

SMILES

COC1=CC(OC)=CC=C1/C=C2CCCN=C\2C3=CC=CN=C3.Cl[H].Cl[H]

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.76%

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Product Name:
GTS-21 dihydrochloride
Cat. No.:
HY-14564A
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GTS-21 dihydrochloride

Cat. No.: HY-14564A