1. Immunology/Inflammation
    NF-κB
    Metabolic Enzyme/Protease
    Apoptosis
  2. COX
    Reactive Oxygen Species
    Apoptosis
    Ferroptosis
    Endogenous Metabolite
  3. Gallic acid hydrate

Gallic acid hydrate (Synonyms: 3,4,5-Trihydroxybenzoic acid hydrate)

Cat. No.: HY-N0523A
Handling Instructions

Gallic acid (3,4,5-Trihydroxybenzoic acid) hydrate is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2). Gallic acid hydrate has various activities, such as antimicrobial, antioxidant, antimicrobial, anti-inflammatory, and anticance activities.

For research use only. We do not sell to patients.

Gallic acid hydrate Chemical Structure

Gallic acid hydrate Chemical Structure

CAS No. : 5995-86-8

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Based on 1 publication(s) in Google Scholar

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Description

Gallic acid (3,4,5-Trihydroxybenzoic acid) hydrate is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2)[1]. Gallic acid hydrate has various activities, such as antimicrobial, antioxidant, antimicrobial, anti-inflammatory, and anticance activities[2].

IC50 & Target[1]

COX-2

 

Human Endogenous Metabolite

 

In Vitro

Gallic acid is an antioxidant which can inhibit both COX-2[1]. After 18 h treatment with Gallic acid, the number of viable neutrophils is dramatically decreased from 40.3% to 27.7%, highly comparable with 26.4% for untreated neutrophils. Gallic acid fails to attenuate isoproterenol-induced myocytolysis[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The food intake (2.6±0.08 g/day, p=0.69) and the body weight (2.5±0.69 g, p=0.76) of the Gallic acid group do not differ significantly from those of the control group (food intake; 2.41±0.14 g/day and the body weight; 2.83±0.84 g/day). The blood glucose tolerance in the Gallic acid group is significantly improved after 2 weeks of treatment. The blood glucose tolerance of the Gallic acid group after a treatment period of 2 weeks is also significantly better than that of the control group at 90 and 120 min ( p<0.05). The serum triglyceride concentration in the Gallic acid group (0.67±0.03 mM, p<0.05) is significantly reduced relative to that of the control group (1.08±0.20 mM). The total cholesterol concentration is similar in the control (3.19±0.27 mM) and Gallic acid (3.01±0.18 mM) groups[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

188.13

Formula

C₇H₈O₆

CAS No.

5995-86-8

SMILES

O=C(O)C1=CC(O)=C(O)C(O)=C1.O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
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Keywords:

Gallic acid3,4,5-Trihydroxybenzoic acidCOXReactive Oxygen SpeciesApoptosisFerroptosisEndogenous MetaboliteCyclooxygenaseantimicrobialantioxidantanti-inflammatoryanticancerInhibitorinhibitorinhibit

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Gallic acid hydrate
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