2. Cell Cycle/DNA Damage Anti-infection
  3. Nucleoside Antimetabolite/Analog SARS-CoV Virus Protease
  4. Carmofur

Carmofur  (Synonyms: HCFU)

Cat. No.: HY-B0182 Purity: 99.91%
COA Handling Instructions

Carmofur (HCFU), a derivative of 5-Fluorouracil, is an antineoplastic agent. Carmofur is an inhibitor of acid ceramidase with an IC50 of 79 nM for the rat enzyme. Carmofur inhibits the SARS-CoV-2 main protease (Mpro). Carmofur Inhibits SARS-CoV-2 in Vero E6 cell with an EC50 of  24.3  μM.

For research use only. We do not sell to patients.

Carmofur Chemical Structure

Carmofur Chemical Structure

CAS No. : 61422-45-5

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Solid + Solvent
10 mM * 1 mL in DMSO
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Solid
100 mg USD 60 In-stock
500 mg USD 84 In-stock
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Based on 3 publication(s) in Google Scholar

Carmofur Related Antibodies

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Description

Carmofur (HCFU), a derivative of 5-Fluorouracil, is an antineoplastic agent. Carmofur is an inhibitor of acid ceramidase with an IC50 of 79 nM for the rat enzyme. Carmofur inhibits the SARS-CoV-2 main protease (Mpro). Carmofur Inhibits SARS-CoV-2 in Vero E6 cell with an EC50 of  24.3  μM[1][2].

Molecular Weight

257.26

Appearance

Solid

Formula

C11H16FN3O3
CAS No.
SMILES

O=C(N(C(N1)=O)C=C(F)C1=O)NCCCCCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (388.71 mM)

H2O : 0.67 mg/mL (2.60 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8871 mL 19.4356 mL 38.8712 mL
5 mM 0.7774 mL 3.8871 mL 7.7742 mL
10 mM 0.3887 mL 1.9436 mL 3.8871 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: 2.08 mg/mL (8.09 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (8.09 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.08 mg/mL (8.09 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.95%

COA (244 KB) HNMR (170 KB) LCMS (470 KB)

Handling Instructions (2659 KB)
References
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Carmofur Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Carmofur61422-45-5HCFUNucleoside Antimetabolite/AnalogSARS-CoVVirus ProteaseSARS coronavirusantineoplasticSARS-CoV-2proteaseMproderivative5-fluorouracilInhibitorinhibitorinhibit

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