1. Cell Cycle/DNA Damage
  2. Nucleoside Antimetabolite/Analog

Carmofur (Synonyms: HCFU)

Cat. No.: HY-B0182 Purity: 99.95%
Handling Instructions

Carmofur is a derivative of fluorouracil, an antimetabolite used as an antineoplastic agent.

For research use only. We do not sell to patients.

Carmofur Chemical Structure

Carmofur Chemical Structure

CAS No. : 61422-45-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
100 mg USD 60 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
500 mg USD 84 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
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5 g   Get quote  

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  • Biological Activity

  • Technical Information

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  • References

Description

Carmofur is a derivative of fluorouracil, an antimetabolite used as an antineoplastic agent. Target: Nucleoside antimetabolite/analog Carmofur, which is used in the clinic to treat colorectal cancers, is a potent AC inhibitor and that this property is essential to its anti-proliferative effects. Carmofur inhibited AC activity with a median effective concentration (IC50) of 29 ± 5 nM (mean ± standard error of the mean, s.e.m.; n = 4), whereas 5-FU had no such effect (IC50>1 mM). systemic administration of carmofur (10 or 30 mg-kg-1, intraperitoneal, i.p.) to mice produced a dose-dependent inhibition of AC activity in various tissues, including lungs and brain cortex.

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8871 mL 19.4356 mL 38.8712 mL
5 mM 0.7774 mL 3.8871 mL 7.7742 mL
10 mM 0.3887 mL 1.9436 mL 3.8871 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

257.26

Formula

C₁₁H₁₆FN₃O₃

CAS No.

61422-45-5

SMILES

O=C(N(C(N1)=O)C=C(F)C1=O)NCCCCCC

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Carmofur
Cat. No.:
HY-B0182
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Carmofur

Cat. No.: HY-B0182