Anti-inflammatory agent 47
Flo8 is a potent anti-inflammatory and antioxidant compound. Flo8 inhibits the release of intracellular reactive oxygen species (ROS) and nitric oxide (NO) and suppresses neuronal apoptotic by inhibiting inflammatory and apoptotic signaling pathways. Flo8 can be used for Parkinson's Disease (PD) research.
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- CAS No.: 2925288-12-4
- Formule: C25H18N2O3
- Masse moléculaire:394.42
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Activité biologique
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Chemical Information
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Activité biologique
Description
In Vitro
Compound Flo8 (5 μM, 10 μM, 18 h) has less inhibitory effect on BV2 cell viability[1].
Compound Flo8 (5 μM, 18 h) exhibits significant inhibitory activity against ROS and NO production in BV2 cells[1].
Compound Flo8 (5 μM, 10 μM, 18 h) reduces the apoptosis level of SH-SY5Y cells by decreasing the expression of inflammatory factors in BV2 cells[1].
Compound Flo8 (5 μM, 10 μM, 18 h) inhibits LPS-induced M1 polarization and promotes M2 polarization in microglia[1].
Compound Flo8 (5 μM, 10 μM, 18 h) inhibits LPS-induced phosphorylation of ERK, p38 and JNK in BV2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:BV2 cells
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Concentration:5 μM, 10 μM
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Incubation Time:18 h
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Result:Exhibited low cytotoxicity at 5 μM concentration and showed minimal toxicity at 10 μM for BV2 cells.
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Cell Line:BV2 cells
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Concentration:5 μM, 10 μM
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Incubation Time:18 h
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Result:Suppressed LPS-induced expression of M1 markers and increased the mRNA level of CD206, Arg-1, and IL-10 in BV2 cells.
Decreased the mRNA expression levels of apoptosis-related genes BAX, Caspase3 and Cleaved Caspase3 but increased the expression levels of Bcl-2 in SH-SY5Y cells.
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Cell Line:BV2 cells
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Concentration:5 μM, 10 μM
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Incubation Time:18 h
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Result:Inhibited phosphorylation of ERK, p38 and JNK in BV2 cells.
Inhibited LPS-induced expression of p-Iκ B-α, p-NF-κB in BV2 cells.
Decreased the protein expression levels of apoptosis-related genes BAX, Caspase3 and Cleaved Caspase3 but increased the expression levels of Bcl-2 in SH-SY5Y cells.
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Cell Line:BV2 cells
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Concentration:5 μM, 10 μM
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Incubation Time:18 h
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Result:Inhibited the translocation of NF-κB from the cytoplasm to the nucleus in BV2 cells.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:MPTP C57BL/6J mice model[1]
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Dosage:15 mg/kg, 35 mg/kg
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Administration:Intraperitoneal injection (i.p.)
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Result:Increased the mRNA expression of CD86, TNF-α, IL-6 and IL-1β but decreased CD206, Arg-1 and IL-10 in brain tissue.
Inhibited the expression of MPTP-induced phosphorylation of p38, ERK, JNK and NF-κ B.
Reduced dopamine levels in mouse serum in the MPTP group.
Increased the protein expression of Caspase3 and BAX but decreased the expression of Bcl2 after MPTP induction in brain tissue.
Chemical Information
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CAS No. 2925288-12-4
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Masse moléculaire 394.42
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Formule C25H18N2O3
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SMILES
O=C1C(C)=C(C2=CC=CC=C2)OC3=C1C=CC=C3C4=NC(C5=CC=CC(C)=C5)=NO4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-inflammatory agent 47 Related Classifications
HY-155568 Related Classifications
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