1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)

Fraxin (Synonyms: Fraxoside)

Cat. No.: HY-N0579
Handling Instructions

Fraxin isolated from Acer tegmentosum, F. ornus or A. hippocastanum, is a glucoside of fraxetin and reported to exert potent anti-oxidative stress action, anti-inflammatory and antimetastatic properties. Fraxin shows its antioxidative effect through inhibition of cyclo AMP phosphodiesterase enzyme.

For research use only. We do not sell to patients.

Fraxin Chemical Structure

Fraxin Chemical Structure

CAS No. : 524-30-1

Size Price Stock
5 mg USD 90 Get quote
10 mg USD 150 Get quote
25 mg USD 320 Get quote

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Fraxin isolated from Acer tegmentosum, F. ornus or A. hippocastanum, is a glucoside of fraxetin and reported to exert potent anti-oxidative stress action[1], anti-inflammatory and antimetastatic properties. Fraxin shows its antioxidative effect through inhibition of cyclo AMP phosphodiesterase enzyme[2].

IC50 & Target

Cyclo AMP phosphodiesterase enzyme[2].

In Vitro

Fraxin (100 μM) is non-cytotoxic on Hep G2 cells. Fraxin at non-cytotoxic concentrations significantly decreases the t-BHP-induced ROS generation in a dose-dependent manner[1].
Fraxin (0.5 mM) shows free radical scavenging effect at high concentration and cell protective effect against H2O2-mediated oxidative stress[2].

In Vivo

Fraxin (50 mg/kg, p.o.) significantly blocks the CCl4-induced elevation of ALT and AST. Fraxin (10 and 50 mg/kg, p.o.) significantly reduces the GSSG levels (1.7±0.3 and 1.5±0.2 nM/g liver, respectively) compared with the GSSG levels of the CCl4-treated group[1].

Solvent & Solubility
In Vitro: 

10 mM in H2O

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7004 mL 13.5022 mL 27.0044 mL
5 mM 0.5401 mL 2.7004 mL 5.4009 mL
10 mM 0.2700 mL 1.3502 mL 2.7004 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

370.31

Formula

C₁₆H₁₈O₁₀

CAS No.

524-30-1

SMILES

OC1=C(OC)C=C(C=C2)C(OC2=O)=C1O[[email protected]@H]([[email protected]@H]([[email protected]@H](O)[[email protected]@H]3O)O)O[[email protected]@H]3CO

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Fraxin
Cat. No.:
HY-N0579
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Fraxin

Cat. No.: HY-N0579