1. GPCR/G Protein
  2. Prostaglandin Receptor

Benorilate (Synonyms: Benoral; Salipran)

Cat. No.: HY-107795 Purity: 99.80%
Handling Instructions

Benorylate (Benoral) is the esterification product of paracetamol and acetylsalicylic acid. It has anti-inflammatory, analgesic and antipyretic properties. Benorylate could also inhibit prostaglandin (PG) synthesis.

For research use only. We do not sell to patients.

Benorilate Chemical Structure

Benorilate Chemical Structure

CAS No. : 5003-48-5

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
100 mg USD 50 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Benorylate (Benoral) is the esterification product of paracetamol and acetylsalicylic acid. It has anti-inflammatory, analgesic and antipyretic properties. Benorylate could also inhibit prostaglandin (PG) synthesis.

IC50 & Target

Prostaglandin[4].

In Vitro

Benorilate is an esterified aspirin preparation whose antirheumatic properties are reported to be as good as those of aspirin[1].
Benorylate causes a large decrease in the liver’s conversion rate of lactate into glucose, an important component of glucose homeostasis. Benorylate also impairs the urea synthesis rate from ammonia, another important function of the liver[2].

In Vivo

Benorylate is probably absorbed as the intact molecule which accounts for its good gastric tolerance[3].
Benorylate could inhibit PG synthesis in laboratory animals and in human tissue[4].

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (398.98 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1918 mL 15.9591 mL 31.9183 mL
5 mM 0.6384 mL 3.1918 mL 6.3837 mL
10 mM 0.3192 mL 1.5959 mL 3.1918 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.64 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (6.64 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.64 mM); Clear solution

References
Molecular Weight

313.30

Formula

C₁₇H₁₅NO₅

CAS No.

5003-48-5

SMILES

O=C(OC1=CC=C(NC(C)=O)C=C1)C2=CC=CC=C2OC(C)=O

Storage

4°C, protect from light

Shipping

Room temperature in continental US; may vary elsewhere

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Benorilate
Cat. No.:
HY-107795
Quantity:

Benorilate

Cat. No.: HY-107795