1. Immunology/Inflammation
  2. NOD-like Receptor (NLR)
    Aryl Hydrocarbon Receptor
  3. Cardamonin

Cardamonin (Synonyms: Cardamomin; Alpinetin chalcone)

Cat. No.: HY-N0279 Purity: 98.54%
Handling Instructions

Cardamonin (Cardamomin), a natural flavone isolated from Alpinia katsumadai Hayata, acts as an aryl hydrocarbon receptor (AhR) activator. Cardamonin alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway.

For research use only. We do not sell to patients.

Cardamonin Chemical Structure

Cardamonin Chemical Structure

CAS No. : 18956-16-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 75 In-stock
Estimated Time of Arrival: December 31
5 mg USD 68 In-stock
Estimated Time of Arrival: December 31
10 mg USD 116 In-stock
Estimated Time of Arrival: December 31
50 mg USD 350 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 4 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Cardamonin purchased from MCE. Usage Cited in: Biomed Pharmacother. 2019 Dec.

    Cardamonin promotes the Nrf2-ARE regulated cytoprotective genes in HL-1 cells dependent on Nrf2. western blot analysis were used to determine Nrf2, HO1, NQO1 and GCLM expression levels in HL-1 cells treated with the indicated concentrations of CAR (0, 25, 50 and 100 μM) for 24 h.

    Cardamonin purchased from MCE. Usage Cited in: Biomed Pharmacother. 2019 Dec.

    Cardamonin promotes the Nrf2-ARE regulated cytoprotective genes in HL-1 cells dependent on Nrf2. Western blot analysis of Nrf2, HO1, NQO1 and GCLM.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Cardamonin (Cardamomin), a natural flavone isolated from Alpinia katsumadai Hayata, acts as an aryl hydrocarbon receptor (AhR) activator. Cardamonin alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway[1].

    IC50 & Target

    NLRP3

     

    Molecular Weight

    270.28

    Formula

    C₁₆H₁₄O₄

    CAS No.

    18956-16-6

    SMILES

    O=C(C1=C(OC)C=C(O)C=C1O)/C=C/C2=CC=CC=C2

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 125 mg/mL (462.48 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.6999 mL 18.4993 mL 36.9987 mL
    5 mM 0.7400 mL 3.6999 mL 7.3997 mL
    10 mM 0.3700 mL 1.8499 mL 3.6999 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.17 mg/mL (8.03 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 98.54%

    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.
    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    CardamoninCardamomin Alpinetin chalconeNOD-like Receptor (NLR)Aryl Hydrocarbon ReceptorAhRInhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product name

     

    Salutation

    Applicant name *

     

    Email address *

    Phone number *

     

    Organization name *

    Country or Region *

     

    Requested quantity *

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product name:
    Cardamonin
    Cat. No.:
    HY-N0279
    Quantity:
    MCE Japan Authorized Agent: