2. NF-κB Stem Cell/Wnt JAK/STAT Signaling Apoptosis
  3. NF-κB STAT Wnt β-catenin Bcl-2 Family Apoptosis
  4. Cardamonin

Cardamonin  (Synonyms: Cardamomin; Alpinetin chalcone)

Cat. No.: HY-N0279 Purity: 98.38%
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Cardamonin can be found from cardamom, and target various signaling molecules, transcriptional factors, cytokines and enzymes. Cardamonin can inhibit mTOR, NF-κB, Akt, STAT3, Wnt/β-catenin and COX-2. Cardamonin shows anticancer, anti-inflammatory, antimicrobial and antidiabetic activities.

For research use only. We do not sell to patients.

Cardamonin Chemical Structure

Cardamonin Chemical Structure

CAS No. : 18956-16-6

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 83 In-stock
Solution
10 mM * 1 mL in DMSO USD 83 In-stock
Solid
5 mg USD 75 In-stock
10 mg USD 128 In-stock
50 mg USD 385 In-stock
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Based on 11 publication(s) in Google Scholar

Cardamonin Related Antibodies

Top Publications Citing Use of Products

    Cardamonin purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2020 Feb;122:109547.  [Abstract]

    Cardamonin promotes the Nrf2-ARE regulated cytoprotective genes in HL-1 cells dependent on Nrf2. western blot analysis were used to determine Nrf2, HO1, NQO1 and GCLM expression levels in HL-1 cells treated with the indicated concentrations of CAR (0, 25, 50 and 100 μM) for 24 h.

    Cardamonin purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2020 Feb;122:109547.  [Abstract]

    Cardamonin promotes the Nrf2-ARE regulated cytoprotective genes in HL-1 cells dependent on Nrf2. Western blot analysis of Nrf2, HO1, NQO1 and GCLM.

    View All NF-κB Isoform Specific Products:

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    NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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    STAT3 STAT5 STAT6 STAT1

    View All Bcl-2 Family Isoform Specific Products:

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    Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

    • Biological Activity

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    Description

    Cardamonin can be found from cardamom, and target various signaling molecules, transcriptional factors, cytokines and enzymes. Cardamonin can inhibit mTOR, NF-κB, Akt, STAT3, Wnt/β-catenin and COX-2. Cardamonin shows anticancer, anti-inflammatory, antimicrobial and antidiabetic activities[1][2].

    In Vitro

    Cardamonin (5-40 μM, 24 or 48 h) treatment inhibits gastric cancer cell growth[3].
    Cardamonin (10-30 μM, 24 or 48 h) treatment can regulate the expression of apoptosis relative protein[3].
    Cardamonin (10-30 μM, 24 or 48 h) treatment can inhibit STAT3 phosphorylation[3].
    Cardamonin (0-100 μM, 24 h) treatment improves the anti-oxidative capacity in HL-1 cells[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Cardamonin Related Antibodies

    Cell Viability Assay[3]

    Cell Line: AGS, MGC-803, BGC-823 cells
    Concentration: 5, 10, 20, 30, 40 μM
    Incubation Time: 24 or 48 hours
    Result: Inhibited cell growth in a concentration-dependent manner.

    Western Blot Analysis[3]

    Cell Line: AGS, MGC-803, BGC-823 cells
    Concentration: 10, 20, 30 μM
    Incubation Time: 24 or 48 hours
    Result: Down-regulated Bcl-2, increased Bax protein expression, and increased the protein expression levels of Caspase-3.

    Western Blot Analysis[3]

    Cell Line: AGS cells
    Concentration: 10, 20, 30 μM
    Incubation Time: 24 or 48 hours
    Result: Suppressed the phosphorylation level of STAT3.

    Western Blot Analysis[4]

    Cell Line: HL-1 cells
    Concentration: 0, 25, 50, 100 μM
    Incubation Time: 24 hours
    Result: Showed anti-oxidant effects in doxorubicin-stimulated cardiomyocytes.
    In Vivo

    Cardamonin (oral gavage; 20, 40 or 80 mg/kg; once) treatments alleviates doxorubicin-induced cardiotoxicity and inhibits apoptosis in doxorubicin-challenged mice[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male C57BL/6 J mice (8 weeks old, 20-22 g)[4]
    Dosage: 20, 40 or 80 mg/kg
    Administration: Oral gavage; 20, 40 or 80 mg/kg; once
    Result: Rescued the reduction of LVEF% and LVFS% by doxorubicin, reduced the increasement of serum LDH, CK-MB and Tn-T levels by doxorubicin in a dose-dependent manner, improved doxorubicin-induced histological changes, and attenuated collagen accumulation in cardiac sections by doxorubicin in a dose-dependent manner.
    Animal Model: Male C57BL/6 J mice (8 weeks old, 20-22 g)[4]
    Dosage: 20, 40 or 80 mg/kg
    Administration: Oral gavage; 20, 40 or 80 mg/kg; once
    Result: Rescued Bcl-2, and inhibited Bax and Caspase-3 cleavage in heart tissues from doxorubicin-challenged mice.
    Molecular Weight

    270.28

    Formula

    C16H14O4
    CAS No.
    Appearance

    Solid

    Color

    Light yellow to yellow

    SMILES

    O=C(C1=C(OC)C=C(O)C=C1O)/C=C/C2=CC=CC=C2
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : 125 mg/mL (462.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.6999 mL 18.4993 mL 36.9987 mL
    5 mM 0.7400 mL 3.6999 mL 7.3997 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.17 mg/mL (8.03 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.17 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (21.7 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
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    g

    Dosing volume
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    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
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    +
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    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation

    Purity: 98.38%

    COA (247 KB) LCMS (93 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 3.6999 mL 18.4993 mL 36.9987 mL 92.4967 mL
    5 mM 0.7400 mL 3.6999 mL 7.3997 mL 18.4993 mL
    10 mM 0.3700 mL 1.8499 mL 3.6999 mL 9.2497 mL
    15 mM 0.2467 mL 1.2333 mL 2.4666 mL 6.1664 mL
    20 mM 0.1850 mL 0.9250 mL 1.8499 mL 4.6248 mL
    25 mM 0.1480 mL 0.7400 mL 1.4799 mL 3.6999 mL
    30 mM 0.1233 mL 0.6166 mL 1.2333 mL 3.0832 mL
    40 mM 0.0925 mL 0.4625 mL 0.9250 mL 2.3124 mL
    50 mM 0.0740 mL 0.3700 mL 0.7400 mL 1.8499 mL
    60 mM 0.0617 mL 0.3083 mL 0.6166 mL 1.5416 mL
    80 mM 0.0462 mL 0.2312 mL 0.4625 mL 1.1562 mL
    100 mM 0.0370 mL 0.1850 mL 0.3700 mL 0.9250 mL
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    Cardamonin Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Cardamonin18956-16-6Cardamomin Alpinetin chalconeNF-κBSTATWntβ-cateninBcl-2 FamilyApoptosisNuclear factor-κBNuclear factor-kappaBBeta cateninanticancer activityanti-inflammatory activityantimicrobial activityantidiabetic activityAGSMGC-803BGC-823HL-1Inhibitorinhibitorinhibit

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