Flavonoid glycosides from Barringtonia acutangula

  • Bioorg Med Chem Lett. 2017 Aug 15;27(16):3776-3781. doi: 10.1016/j.bmcl.2017.06.066.
Le Thi Vien  1 ,  Quach Thi Thanh Van  2 ,  Tran Thi Hong Hanh  1 ,  Phan Thi Thanh Huong  1 ,  Nguyen Thi Kim Thuy  3 ,  Nguyen The Cuong  4 ,  Nguyen Hai Dang  1 ,  Nguyen Van Thanh  1 ,  Nguyen Xuan Cuong  5 ,  Nguyen Hoai Nam  1 ,  Phan Van Kiem  1 ,  Chau Van Minh  6
Affiliations
  • 1. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam.
  • 2. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam; Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam; Viet Tri University of Industry, 09 Tien Son, Viet Tri, Phutho, Viet Nam.
  • 3. Viet Tri University of Industry, 09 Tien Son, Viet Tri, Phutho, Viet Nam.
  • 4. Institute of Ecology and Biological Resources, VAST, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam.
  • 5. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam; Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam. Electronic address: [email protected].
  • 6. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam. Electronic address: [email protected].
PMID: 28688956 DOI: 10.1016/j.bmcl.2017.06.066
Abstract

Using various chromatographic separation techniques, ten flavonoid glycosides, including six new compounds namely barringosides A-F (1-6), were isolated from a methanol extract of the Barringtonia acutangula leaves. The structure elucidation was confirmed by spectroscopic analyses, including 1D and 2D NMR, and HR ESI MS. Their inhibitory effects on LPS-induced NO production in RAW264.7 cells were also evaluated. Among the isolated compounds, quercetin 3-O-β-d-(6-p-hydroxybenzoyl)galactopyranoside (9) showed significant effect with an IC50 of 20.00±1.68µM. This is the first report of these flavonoid glycosides from Barringtonia genus and their inhibition on LPS-induced NO production in RAW264.7 cells was reported here for the first time.

Keywords
Barringtonia acutangula; Flavonoid glycoside; Lecythidaceae; NO production.