Triterpene saponins and megastigmane glucosides from Camellia bugiamapensis

  • Bioorg Med Chem Lett. 2017 Feb 1;27(3):557-561. doi: 10.1016/j.bmcl.2016.12.020.
Nguyen Thi Huong  1 ,  Le Thi Vien  1 ,  Tran Thi Hong Hanh  1 ,  Nguyen Hai Dang  1 ,  Nguyen Van Thanh  1 ,  Nguyen Xuan Cuong  1 ,  Nguyen Hoai Nam  2 ,  Luu Hong Truong  3 ,  Ninh Khac Ban  1 ,  Phan Van Kiem  1 ,  Chau Van Minh  4
Affiliations
  • 1. Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam.
  • 2. Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam. Electronic address: [email protected].
  • 3. Southern Institute of Ecology, VAST, 01 Mac Dinh Chi, District 1, Ho Chi Minh City, Viet Nam.
  • 4. Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam. Electronic address: [email protected].
PMID: 28011215 DOI: 10.1016/j.bmcl.2016.12.020
Abstract

Two new triterpene saponins, camelliosides I and J (1 and 2), two new megastigmane glycosides, camellistigosides A and B (3 and 4), and two known megastigmane glycosides, icariside B1 (5) and (6S,9R)-roseoside (6), were isolated from a methanol extract of the Camellia bugiamapensis leaves using various chromatographic separation techniques. Their structures were elucidated based on spectroscopic analyses, including HR ESI MS, CD, 1D and 2D NMR. Their inhibitory effects on LPS-induced NO production in RAW264.7 cells were evaluated. This is the first report of the chemical constituents and biological activity of C. bugiamapensis.

Keywords
Camellia bugiamapensis; NO production; Theaceae.