1. Immunology/Inflammation
  2. COX
  3. α-​Chaconine

α-​Chaconine 

Cat. No.: HY-129113
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α-Chaconine, isolated from a Solanum tuberosum L. cv Jayoung, inhibits the expressions of COX-2, IL-1β, IL-6, and TNF-α at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of iNOS and COX-2 at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects.

For research use only. We do not sell to patients.

α-​Chaconine Chemical Structure

α-​Chaconine Chemical Structure

CAS No. : 20562-03-2

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Description

α-Chaconine, isolated from a Solanum tuberosum L. cv Jayoung, inhibits the expressions of COX-2, IL-1β, IL-6, and TNF-α at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of iNOS and COX-2 at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects[1].

IC50 & Target

COX-2

 

In Vitro

α-Chaconine attenuates the transcriptional activity of activator protein-1 (AP-1) by reducing the translocation and phosphorylation of c-Jun.α-Chaconine suppresses lipopolysaccharide-induced pro-inflammatory mediators via AP-1 inactivation in RAW 264.7 macrophages and protects mice from endotoxin shock.α-Chaconine also suppresses the phosphorylation of TGF-β-activated kinase-1 (TAK1), which lies upstream of MKK7/JNK signaling[1].

Molecular Weight

852.06

Formula

C₄₅H₇₃NO₁₄

CAS No.

20562-03-2

SMILES
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Keywords:

α-​ChaconineCOXCyclooxygenaseInflammatorymediatorCOX-2IL-1βIL-6TNF-αiNOSAP-1Inhibitorinhibitorinhibit

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α-​Chaconine
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