1. Immunology/Inflammation
  2. COX
  3. COX-2-IN-24

COX-2-IN-24 is an orally active inhibitor of COX-2 with IC50 value of 0.17 μM, shows anti-inflammatory and low ulcerogenic activities.

For research use only. We do not sell to patients.

COX-2-IN-24 Chemical Structure

COX-2-IN-24 Chemical Structure

CAS No. : 2417995-10-7

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Description

COX-2-IN-24 is an orally active inhibitor of COX-2 with IC50 value of 0.17 μM, shows anti-inflammatory and low ulcerogenic activities.

IC50 & Target

COX-2

0.17 μM (IC50)

In Vivo

COX-2-IN-24 (Intraperitoneal injection; 9mg/100g; once an hour; 4 hours) shows anti-inflammatory activity in the carrageenan-induced rat paw edema model[1].
COX-2-IN-24 (Oral gavage; 9mg/100g; once a day; 3 days) shows low ulcerogenic activity in the received 1% gum acacia (suspending vehicle) orally male albino rats model [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mature male albino rats[1]
Dosage: 9mg/100g
Administration: Intraperitoneal injection; 9mg/100g; once an hour; 4 hours
Result: Exhibited a promising anti-inflammatory activity in the carrageenan-induced rat paw edema model.
Animal Model: Mature male albino rats[1]
Dosage: 9mg/100g
Administration: Oral gavage; 9mg/100g; once a day; 3 days
Result: Exhibited low ulcerogenic activity in the received 1% gum acacia (suspending vehicle) orally male albino rats model.
Molecular Weight

574.51

Formula

C24H24BrN5O3S2

CAS No.
SMILES

O=S(C1=CC(C(N2C3=CC=C(Br)C=C3)=NNC2=S)=CC(NCCCC)=C1OC4=CC=CC=C4)(N)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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COX-2-IN-24 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
COX-2-IN-24
Cat. No.:
HY-147963
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