MAO-B-IN-19
MAO-B-IN-19 is a selective MAO-B inhibitor with an IC50 of 0.67 μM. MAO-B-IN-19 shows neuroprotective and anti-inflammatory properties.
For research use only. We do not sell to patients.
- CAS No.: 152897-41-1
- Formula: C15H11FO2
- Molecular Weight:242.25
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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MAO-B 0.67 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
20.5 μM
Compound: 3m
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Cytotoxicity against human HCT116 cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity against human HCT116 cells assessed as cell viability after 48 hrs by MTT assay
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[PMID: 23771043] |
| HeLa | IC50 |
22.6 μM
Compound: 1e, 1PF
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Cytotoxicity against human HeLa cells assessed as decrease in cell survival after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as decrease in cell survival after 72 hrs by MTT assay
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[PMID: 23501110] |
| K562 | IC50 |
17.9 μM
Compound: 1e, 1PF
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Cytotoxicity against human K562 cells assessed as decrease in cell survival after 72 hrs by MTT assay
Cytotoxicity against human K562 cells assessed as decrease in cell survival after 72 hrs by MTT assay
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[PMID: 23501110] |
| MCF7 | IC50 |
26 μM
Compound: 1e, 1PF
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Cytotoxicity against human MCF7 cells assessed as decrease in cell survival after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as decrease in cell survival after 72 hrs by MTT assay
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[PMID: 23501110] |
| PC-3 | IC50 |
30.4 μM
Compound: 1e, 1PF
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Cytotoxicity against human PC3 cells assessed as decrease in cell survival after 72 hrs by MTT assay
Cytotoxicity against human PC3 cells assessed as decrease in cell survival after 72 hrs by MTT assay
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[PMID: 23501110] |
| RAW264.7 | IC50 |
>10 μM
Compound: 12
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Inhibition of LPS-stimulated ROS production in mouse RAW264.7 cells preincubated for 1 hr followed by LPS stimulation for 24 hrs measured after 30 mins by CMH2DCFDA probe-based fluorescence assay
Inhibition of LPS-stimulated ROS production in mouse RAW264.7 cells preincubated for 1 hr followed by LPS stimulation for 24 hrs measured after 30 mins by CMH2DCFDA probe-based fluorescence assay
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[PMID: 28159411] |
MAO-B-IN-19 (compound 3f) significantly inhibits self-induced Aβ1-42 aggregation and shows remarkable neuroprotective effects on Aβ25-35-induced PC12 cell injury. MAO-B-IN-19 is a selective metal chelator and could inhibit Cu2+-induced Aβ1-42 aggregation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 152897-41-1
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Molecular Weight 242.25
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Formula C15H11FO2
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SMILES
C1=CC=C(C(=C1)C(=O)/C=C/C2=CC=C(C=C2)F)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MAO-B-IN-19 Related Classifications
HY-W335927 Related Classifications
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