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Umirolimus 

Cat. No.: HY-122402
Handling Instructions

Umirolimus, a macrocyclic triene lactone Rapamycin derivative, is powerful immunosuppressant and anti-inflammatory agent. Umirolimus has highly lipophilicity and can be used drug-eluting stent (DES) applications.

For research use only. We do not sell to patients.

Umirolimus Chemical Structure

Umirolimus Chemical Structure

CAS No. : 851536-75-9

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Description

Umirolimus, a macrocyclic triene lactone Rapamycin derivative, is powerful immunosuppressant and anti-inflammatory agent. Umirolimus has highly lipophilicity and can be used drug-eluting stent (DES) applications[1].

In Vitro

Umirolimus is a macrocyclic triene lactone, developed with pharmacological properties specifically tailored for localized drug delivery. Umirolimus can be used drug-eluting stent (DES) applications. Owing to its enhanced lipophilicity,it is strongly attracted to binding sites within the vessel wall and small, tortuous vessels, and contributing to cellular absorption and sustained distribution in the vessel wall surrounding the stent[1].
Umirolimus prevents progression of the cell cycle in G1 phase by inhibiting IL-2/mTOR-mediated P70-KD S6 protein kinase activation. Umirolimus inhibits T-cell growth, as well as smooth muscle cell growth[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The elimination half-life of Umirolimus is approximately 25 h in whole blood[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

986.28

Formula

C₅₅H₈₇NO₁₄

CAS No.

851536-75-9

SMILES
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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

UmirolimusOthersImmunosuppressantanti-inflammatoryantiproliferative,drug-elutingstentInhibitorinhibitorinhibit

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Umirolimus
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