1. Metabolic Enzyme/Protease Anti-infection
  2. Amylases Bacterial
  3. 1-Hydroxyphenazine

1-Hydroxyphenazine  (Synonyms: Hemipyocyanine; 1-Phenazinol; Hemi-pyocyanin)

Cat. No.: HY-W068682
Handling Instructions

1-Hydroxyphenazine (Hemipyocyanine; 1-Phenazinol; Hemi-pyocyanin) is an inhibitor for α-Amylase with an IC50 of 3.1 μg/mL. 1-Hydroxyphenazine exhibits anticancer and anti-inflammatory activity against cells A549, 1321N1 and RAW264.7, antifungal and antibacterial activity against strains Candida albicans, Aspergillus fumigatus, Escherichia coli and Xanthomonas campestris.

For research use only. We do not sell to patients.

1-Hydroxyphenazine Chemical Structure

1-Hydroxyphenazine Chemical Structure

CAS No. : 528-71-2

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Description

1-Hydroxyphenazine (Hemipyocyanine; 1-Phenazinol; Hemi-pyocyanin) is an inhibitor for α-Amylase with an IC50 of 3.1 μg/mL[1]. 1-Hydroxyphenazine exhibits anticancer and anti-inflammatory activity against cells A549, 1321N1 and RAW264.7, antifungal and antibacterial activity against strains Candida albicans, Aspergillus fumigatus, Escherichia coli and Xanthomonas campestris[2][3][4][5].

In Vitro

1-Hydroxyphenazine (0.1-100 μM) inhibits proliferation against brain astrocytoma 1321N1 cells through formation of acidic vesicular organelle, which is a hallmark of cell autophagy, exhibits potential toxicity in central nervous system (CNS)[2].
Hydroxyphenazine (0-10 μg/mL) inhibits secretion of TNF-α and M1 cell polarization, inhibits LPS induced inflammation in RAW264.7 cells without significant toxicity[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[3]

Cell Line: RAW264.7
Concentration: 0-10 μg/mL
Incubation Time: 24 h
Result: Inhibited proliferation of RAW264.7 in a dose-dependent maner.

RT-PCR[3]

Cell Line: RAW264.7
Concentration: 0-10 μg/mL
Incubation Time: 24 h
Result: Decreased levels of TNF-α, IL-1β and IL-6 mRNA expressions.
Molecular Weight

196.20

Formula

C12H8N2O

CAS No.
SMILES

OC1=CC=CC2=NC3=CC=CC=C3N=C21

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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1-Hydroxyphenazine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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1-Hydroxyphenazine
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