528-71-2
528-71-2
Chemical Structure
1-Hydroxyphenazine
Synonym(s): Hemipyocyanine; 1-Phenazinol; Hemi-pyocyanin
- CAS No.: 528-71-2
- Formula:C12H8N2O
- Molecular Weight:196.20
IUPAC Name: phenazin-1-ol
InChIKey: SVRNCBGWUMMBQB-UHFFFAOYSA-N
SMILES: OC1=CC=CC2=NC3=CC=CC=C3N=C21
Biological Activity: 1-Hydroxyphenazine (Hemipyocyanine; 1-Phenazinol; Hemi-pyocyanin) is an inhibitor for α-Amylase with an IC50 of 3.1 μg/mL[1]. 1-Hydroxyphenazine exhibits anticancer and anti-inflammatory activity against cells A549, 1321N1 and RAW264.7, antifungal and antibacterial activity against strains Candida albicans, Aspergillus fumigatus, Escherichia coli and Xanthomonas campestris[2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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1-Hydroxyphenazine | 99.80% | 1-Hydroxyphenazine (Hemipyocyanine; 1-Phenazinol; Hemi-pyocyanin) is an inhibitor for α-Amylase with an IC50 of 3.1 μg/mL. 1-Hydroxyphenazine exhibits anticancer and anti-inflammatory activity against cells A549, 1321N1 and RAW264.7, antifungal and antibacterial activity against strains Candida albicans, Aspergillus fumigatus, Escherichia coli and Xanthomonas campestris. | ||||||||||||||||||||
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References
- [1]. Nguyen TH, et al., Novel α-Amylase Inhibitor Hemi-Pyocyanin Produced by Microbial Conversion of Chitinous Discards. Mar Drugs. 2022 Apr 23;20(5):283. [Content Brief]
- [2]. McFarland AJ, et al., Inhibition of autophagy by 3-methyladenine protects 1321N1 astrocytoma cells against pyocyanin- and 1-hydroxyphenazine-induced toxicity. Arch Toxicol. 2012 Feb;86(2):275-84 [Content Brief]
- [3]. Xiao J, et al., Anti-Inflammatory Effects of an Extract from Pseudomonas aeruginosa and Its Purified Product 1-Hydroxyphenazine on RAW264.7 Cells. Curr Microbiol. 2021 Jul;78(7):2762-2773. [Content Brief]
- [4]. Prabhu MS, et al., Purification and molecular and biological characterisation of the 1-hydroxyphenazine, produced by an environmental strain of Pseudomonas aeruginosa. World J Microbiol Biotechnol. 2014 Dec;30(12):3091-9. [Content Brief]
- [5]. Kerr JR, et al., Pseudomonas aeruginosa pyocyanin and 1-hydroxyphenazine inhibit fungal growth. J Clin Pathol. 1999 May;52(5):385-7. [Content Brief]
