9-Aminoacridine
Based on 4 publication(s) in Google Scholar
9-Aminoacridine, a fluorescent probe, acts as an indicator of pH for quantitative determination of transmembrane pH gradients (inside acidic). 9-Aminoacridine is an antimicrobial. 9-Aminoacridine exerts its antimicrobial activity by interacting with specific bacterial DNA and disrupting the proton motive force in K. pneumoniae. 9-Aminoacridine is a HIV-1 inhibitor and inhibits HIV LTR transcription highly dependent on the presence and location of the amino moiety. 9-Aminoacridine inhibits virus replication in HIV-1 infected cell lines. 9-Aminoacridine is used as a Rifampin (RIF; HY-B0272) adjuvant for the multidrug-resistant K. pneumoniae infections.
For research use only. We do not sell to patients.
- Purity: 99.35%
- CAS No.: 90-45-9
- Formula: C13H10N2
- Molecular Weight:194.24
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) 9-Aminoacridine
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Biological Activity
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HIV-1 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Hepatocyte | IC50 |
120 μM
Compound: 10
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Inhibition of apamin-sensitive SKCa channel of guinea-pig hepatocytes
Inhibition of apamin-sensitive SKCa channel of guinea-pig hepatocytes
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[PMID: 15225721] |
| HL-60 | GI50 |
2 μM
Compound: 9-AA
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Growth inhibition of human HL60 cells
Growth inhibition of human HL60 cells
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[PMID: 20980148] |
| HT-22 | EC50 |
9.19 μM
Compound: 47
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Cytotoxicity against mouse HT22 cells after 24 hrs by MTT assay
Cytotoxicity against mouse HT22 cells after 24 hrs by MTT assay
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[PMID: 24602904] |
| L1210 | IC50 |
2600 nM
Compound: 9
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Evaluated for concentration which when added to cultures of L1210 leukemia cells for a period of 70 hr reduces cell numbers of 50% of control cultures
Evaluated for concentration which when added to cultures of L1210 leukemia cells for a period of 70 hr reduces cell numbers of 50% of control cultures
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[PMID: 3572974] |
| SK-OV-3 | IC50 |
2.53 μM
Compound: 9AA
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Cytotoxicity against human SKOV3 cells transfected with non-targeted vector assessed as reduction in cell viability incubated for 96 hrs in presence of doxycycline by MTT assay
Cytotoxicity against human SKOV3 cells transfected with non-targeted vector assessed as reduction in cell viability incubated for 96 hrs in presence of doxycycline by MTT assay
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[PMID: 31514018] |
| SK-OV-3 | IC50 |
2.57 μM
Compound: 9AA
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Cytotoxicity against human SKOV3 cells transfected with shRNA assessed as reduction in cell viability incubated for 96 hrs in presence of doxycycline by MTT assay
Cytotoxicity against human SKOV3 cells transfected with shRNA assessed as reduction in cell viability incubated for 96 hrs in presence of doxycycline by MTT assay
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[PMID: 31514018] |
| SK-OV-3 | IC50 |
2.78 μM
Compound: 9AA
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Cytotoxicity against human SKOV3 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
Cytotoxicity against human SKOV3 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
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[PMID: 31514018] |
| SK-OV-3 | IC50 |
5.43 μM
Compound: 9AA
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Cytotoxicity against human SKOV3 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Cytotoxicity against human SKOV3 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
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[PMID: 31514018] |
| TOV112D | IC50 |
3.15 μM
Compound: 9AA
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Cytotoxicity against human TOV112D cells expressing NQO2 assessed as reduction in cell viability incubated for 96 hrs by MTT assay
Cytotoxicity against human TOV112D cells expressing NQO2 assessed as reduction in cell viability incubated for 96 hrs by MTT assay
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[PMID: 31514018] |
| TOV112D | IC50 |
3.6 μM
Compound: 9AA
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Cytotoxicity against human TOV112D cells transfected with empty vector assessed as reduction in cell viability incubated for 96 hrs by MTT assay
Cytotoxicity against human TOV112D cells transfected with empty vector assessed as reduction in cell viability incubated for 96 hrs by MTT assay
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[PMID: 31514018] |
9-Aminoacridine has a strong antimicrobial effect on K. pneumoniae, with MICs from 8 to 16?μg/mL[1].
9-Aminoacridine (0-64?μg/mL) shows moderate cytotoxicity to normal (LO2, HK2, HMC3) and tumor (HepG2, 786-O, U251) human cell lines, but when used as a RIF adjuvant, the reduced dosage of 9-Aminoacridine further diminishes its toxicity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:7-week-old ICR female mice with the skin subcutaneous abscess model[2]
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Dosage:15 mg/kg
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Administration:Subcutaneously
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Result:A single dose of 15 mg/kg 9-AA decreased the abscess area.
A single dose of 15 mg/kg 9-AA or 20 mg/kg Rifampin (RIF; HY-B0272) did not significantly reduce the viable bacterial loads in the abscess. The combined use of the drugs significantly decreased the bacterial load by 3.15 log10 CFU/abscess.
Chemical Information
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CAS No. 90-45-9
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Appearance Solid
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Molecular Weight 194.24
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Formula C13H10N2
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Color Light yellow to yellow
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SMILES
NC1=C(C=CC=C2)C2=NC3=CC=CC=C31
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Synonyms
Aminacrine
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (4)
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Journal Impact Factor
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Most Recent
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Nat Commun
2025 May 1;16(1):4078. PMID: 40307217 -
Sci Data
High-content, arrayed compound screens with rhinovirus, influenza A virus and herpes simplex virus infections. [Abstract]2022 Oct 8;9(1):610. PMID: 36209289 -
Microbiol Spectr
Repurposing 9-Aminoacridine as an Adjuvant Enhances the Antimicrobial Effects of Rifampin against Multidrug-Resistant Klebsiella pneumoniae. [Abstract]2023 Jun 15;11(3):e0447422. PMID: 37036368 -
Vet Microbiol
The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]2026 May:316:110992. PMID: 41865607
Solvent & Solubility
DMSO : 100 mg/mL (514.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (537 KB)
- English - EN (537 KB)
- Français - FR (537 KB)
- Deutsch - DE (537 KB)
- Norwegian - NO (537 KB)
- Español - ES (537 KB)
- Swedish - SV (537 KB)
- Italian - IT (537 KB)
- Korean - KR (537 KB)
- Portuguese - PT (537 KB)
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Handling Instructions (2659 KB)
References
[1]. S Grzesiek, et al. The 'delta pH'-probe 9-aminoacridine: response time, binding behaviour and dimerization at the membrane. Biochim Biophys Acta. 1988 Mar 3;938(3):411-24. [Content Brief]
[2]. Pengfei She, et al. Repurposing 9-Aminoacridine as an Adjuvant Enhances the Antimicrobial Effects of Rifampin against Multidrug-Resistant Klebsiella pneumonia. Microbiol Spectr. 2023 Jun 15;11(3):e0447422. [Content Brief]
[3]. Irene Guendel, et al. 9-Aminoacridine inhibition of HIV-1 Tat dependent transcription. Virol J. 2009 Jul 24:6:114. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.1483 mL | 25.7414 mL | 51.4827 mL | 128.7068 mL |
| 5 mM | 1.0297 mL | 5.1483 mL | 10.2965 mL | 25.7414 mL | |
| 10 mM | 0.5148 mL | 2.5741 mL | 5.1483 mL | 12.8707 mL | |
| 15 mM | 0.3432 mL | 1.7161 mL | 3.4322 mL | 8.5805 mL | |
| 20 mM | 0.2574 mL | 1.2871 mL | 2.5741 mL | 6.4353 mL | |
| 25 mM | 0.2059 mL | 1.0297 mL | 2.0593 mL | 5.1483 mL | |
| 30 mM | 0.1716 mL | 0.8580 mL | 1.7161 mL | 4.2902 mL | |
| 40 mM | 0.1287 mL | 0.6435 mL | 1.2871 mL | 3.2177 mL | |
| 50 mM | 0.1030 mL | 0.5148 mL | 1.0297 mL | 2.5741 mL | |
| 60 mM | 0.0858 mL | 0.4290 mL | 0.8580 mL | 2.1451 mL | |
| 80 mM | 0.0644 mL | 0.3218 mL | 0.6435 mL | 1.6088 mL | |
| 100 mM | 0.0515 mL | 0.2574 mL | 0.5148 mL | 1.2871 mL |
9-Aminoacridine Related Classifications
HY-B1422 Related Classifications
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