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  3. Quinacrine dihydrochloride

Quinacrine dihydrochloride (Synonyms: Mepacrine dihydrochloride; SN-390 dihydrochloride)

Cat. No.: HY-13735A Purity: 98.05%
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Quinacrine dihydrochloride (Mepacrine dihydrochloride) is a fluorescent probe for the conformational transitions of the cholinergic receptor protein.

For research use only. We do not sell to patients.

Quinacrine dihydrochloride Chemical Structure

Quinacrine dihydrochloride Chemical Structure

CAS No. : 69-05-6

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10 mM * 1  mL in DMSO USD 66 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Quinacrine dihydrochloride (Mepacrine dihydrochloride) is a fluorescent probe for the conformational transitions of the cholinergic receptor protein. Quinacrine dihydrochloride (Mepacrine dihydrochloride) shows activity in the low μM range with a mean IC50 of 2.30 μM In the patient AML cells. IC50 value: 2.30 μM (for AML cells) Target: in vitro: Quinacrine is a fluorescent probe for the conformational transitions of the cholinergic receptor protein in its membrane-bound state.[1] In the patient AML samples, Quinacrine showed activity in the low μM range with a mean IC50 of 2.30 μM, statistically significantly lower than that of normal PBMCs; 3.54 μM (P=0.0327; Student's t-test). Samples from patients with chronic lymphocytic, acute myeloid and lymphocytic leukemias as well as peripheral blood mononuclear cells (PBMC) were tested in response to 1266 compounds from the LOPAC1280 library. 25 compounds were defined as hits with activity in all leukemia subgroups (<50% cell survival compared with control) at 10 μM drug concentration. Only Quinacrine showed concurrent high activity in all leukemia subgroups and low activity in normal PBMCs and was, therefore, selected for further preclinical evaluation. Quinacrine also induced early inhibition of both DNA and protein synthesis. Quinacrine have repositioning potential for treatment of acute myeloid leukemia by targeting of ribosomal biogenesis.[2]

Clinical Trial
Molecular Weight

472.88

Formula

C₂₃H₃₂Cl₃N₃O

CAS No.

69-05-6

SMILES

CC(NC1=C(C=C(OC)C=C2)C2=NC3=CC(Cl)=CC=C31)CCCN(CC)CC.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 44 mg/mL (93.05 mM)

H2O : 33.33 mg/mL (70.48 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

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Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1147 mL 10.5735 mL 21.1470 mL
5 mM 0.4229 mL 2.1147 mL 4.2294 mL
10 mM 0.2115 mL 1.0574 mL 2.1147 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 98.05%

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Keywords:

QuinacrineMepacrineSN-390SN390SN 390PhospholipaseAutophagyMitophagyMitochondrial AutophagyInhibitorinhibitorinhibit

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Quinacrine dihydrochloride
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HY-13735A
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