Quinacrine hydrochloride hydrate
Based on 9 publication(s) in Google Scholar
Quinacrine hydrochloride hydrate (Mepacrine hydrochloride hydrate) is an antimalarial agent, which possess anticancer effect both in vitro and vivo. Quinacrine hydrochloride hydrate suppresses NF-κB and activates p53 signaling, which results in the induction of the apoptosis.
For research use only. We do not sell to patients.
- Purity: 98.18%
- CAS No.: 6151-30-0
- Formula: C23H36Cl3N3O3
- Molecular Weight:508.91
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Publications Citing Use of MedChemExpress (MCE) Quinacrine hydrochloride hydrate
More- J Biomed Sci. 2025 Feb 5;32(1):15. [Abstract]
- J Neuroinflammation. 2025 Oct 27;22(1):243. [Abstract]
- Phytomedicine. 2025 Sep:145:156981. [Abstract]
- J Pharm Anal. 2025 Dec 15.
- Part Fibre Toxicol. 2024 Mar 7;21(1):13. [Abstract]
- Brain Behav Immun. 2026 Jan 18:134:106296. [Abstract]
- Pharmaceutics. 2022 Jan 12;14(1):176. [Abstract]
- bioRxiv. 2025 Nov 11.
- University of Saskatchewan. 2020 Jun 22.
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Cell Proliferation/Viability Assay
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Cell Proliferation/Viability Assay
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Bio/Physico-chemical Assay
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Biological Activity
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Plasmodium |
Quinacrine (5-20 μM; 24 hours) inhibits the growth of SGC-7901 cells[1].
Quinacrine (7.5 and 15 μM; 24 hours) induces apoptosis in SGC-7901 cells, which is associated with mitochondria-dependent signal pathway and involves p53 upregulation and caspase-3 activation pathway[1].
Quinacrine (15 μM; 24 hours) treatment significantly increased the levels of proapoptotic proteins, including cytochrome c, Bax, and p53, and decreased the levels of antiapoptotic protein Bcl-2, thus shifting the ratio of Bax/Bcl-2 in favor of apoptosis [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SGC-7901 cells
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Concentration:0, 5, 10, 15, and 20 μM
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Incubation Time:24 hours
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Result:Cell viability was inhibited in a dose-dependent manner, and the mean IC50 value is 16.18 μM.
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Cell Line:SGC-7901 cells
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Concentration:7.5 and 15 μM
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Incubation Time:24 hours
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Result:The percentage of apoptotic cells, including the early phase and late phase apoptosis, increased to 26.30%, compared with control group of 3.37%.
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Cell Line:SGC-7901 cells
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Concentration:15 μM
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Incubation Time:24 hours
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Result:The relative quantity of cytochrome c protein was upregulated, increased from 0.10 to 0.24.
The relative quantity of p53 protein was dramatically increased, from 0.06 to 0.19.
The Bax/Bcl-2 ratio was dramatically elevated from 1.21 to 2.59.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female SCID mice with acute myeloid leukemia (AML)-PS model[2]
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Dosage:100 mg/kg
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Administration:Administered by oral gavage (po); three times a week for two consecutive weeks
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Result:In the first AML mouse in vivo study, evaluation of circulating leukemic cells detected in blood samples (in percent of white blood cells (WBC)) at day 30/31 showed 72% human tumor cells in the control mice, whereas in mice treated with Quinacrine, this was only 2.2%.
The MST of control mice was 34 days whereas it was 46 days in Quinacrine-treated mice.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 6151-30-0
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Appearance Solid
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Molecular Weight 508.91
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Formula C23H36Cl3N3O3
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Color Light yellow to yellow
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SMILES
CC(NC1=C(C=C(OC)C=C2)C2=NC3=CC(Cl)=CC=C31)CCCN(CC)CC.[H]Cl.[H]Cl.[H]O[H].[H]O[H]
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Synonyms
Mepacrine hydrochloride hydrate; SN-390 hydrochloride hydrate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (9)
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Journal Impact Factor
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Most Recent
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J Biomed Sci
Targeting the G-quadruplex as a novel strategy for developing antibiotics against hypervirulent drug-resistant Staphylococcus aureus. [Abstract]2025 Feb 5;32(1):15. PMID: 39905515
Quinacrine hydrochloride hydrate purchased from MedChemExpress. Usage Cited in: J Biomed Sci. 2025 Feb 5;32(1):15. [Abstract]
The tabulated datasheet from IC50 data showing the percent inhibition of SAUSA300 cells at 10 µM of G4-ligands (Quinacrine dihydrochloride, etc.) and their IC50 values.
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J Neuroinflammation
2025 Oct 27;22(1):243. PMID: 41146204 -
Phytomedicine
Quinacrine induces autophagy via the Dlg5/AKT pathway to inhibit osteosarcoma cell proliferation and suppresses migration and invasion through the Dlg5/Girdin pathway. [Abstract]2025 Sep:145:156981. PMID: 40541124 -
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Part Fibre Toxicol
Exposure to high dose of polystyrene nanoplastics causes trophoblast cell apoptosis and induces miscarriage. [Abstract]2024 Mar 7;21(1):13. PMID: 38454452
Quinacrine hydrochloride hydrate purchased from MedChemExpress. Usage Cited in: Part Fibre Toxicol. 2024 Mar 7;21(1):13. [Abstract]
Cell viability of trophoblast cells treated with 10 μM Raptinal, 15 μM Quinacrine dihydrochloride, or 500 μg/mL PS-NPs, and co-treated with 10 μM Z-VAD-FMK for 48 h. The results showed that treatment with Raptinal, Quinacrine dihydrochloride, or PS-NPs reduced trophoblast cell viability, and co-treatment with Z-VAD-FMK rescued trophoblast cell viability.
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Brain Behav Immun
Inhibition of the NFATc2/FKBP5 axis alleviates microglial neuroinflammation by regulating arachidonic acid metabolism in Parkinson's disease. [Abstract]2026 Jan 18:134:106296. PMID: 41554345 -
Pharmaceutics
Drug Repurposing for the Identification of Compounds with Anti-SARS-CoV-2 Capability via Multiple Targets. [Abstract]2022 Jan 12;14(1):176. PMID: 35057070
Quinacrine hydrochloride hydrate purchased from MedChemExpress. Usage Cited in: Pharmaceutics. 2022 Jan 12;14(1):176. [Abstract]
Quinacrine (Mepacrine) dihydrochloride inhibited the enzymatic activities of TMPRSS2 and PLpro, with IC50 values of 29.9 μM and 4.4 μM, respectively.
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Solvent & Solubility
H2O : 20 mg/mL (39.30 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Xiaoyang Wu, et al. Quinacrine Inhibits Cell Growth and Induces Apoptosis in Human Gastric Cancer Cell Line SGC-7901. Curr Ther Res Clin Exp. 2012 Feb;73(1-2):52-64. [Content Brief]
[2]. Anna Eriksson, et al. Towards repositioning of quinacrine for treatment of acute myeloid leukemia - Promising synergies and in vivo effects. Leuk Res. 2017 Dec;63:41-46. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 1.9650 mL | 9.8249 mL | 19.6498 mL | 49.1246 mL |
| 5 mM | 0.3930 mL | 1.9650 mL | 3.9300 mL | 9.8249 mL | |
| 10 mM | 0.1965 mL | 0.9825 mL | 1.9650 mL | 4.9125 mL | |
| 15 mM | 0.1310 mL | 0.6550 mL | 1.3100 mL | 3.2750 mL | |
| 20 mM | 0.0982 mL | 0.4912 mL | 0.9825 mL | 2.4562 mL | |
| 25 mM | 0.0786 mL | 0.3930 mL | 0.7860 mL | 1.9650 mL | |
| 30 mM | 0.0655 mL | 0.3275 mL | 0.6550 mL | 1.6375 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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