1. Membrane Transporter/Ion Channel
    Metabolic Enzyme/Protease
  2. Na+/K+ ATPase
    Drug Metabolite
  3. Deslanoside

Deslanoside (Synonyms: Deacetyllanatoside C; Desacetyllanatoside C)

Cat. No.: HY-A0154 Purity: 99.76%
Handling Instructions

Deslanoside (Desacetyllanatoside C) is a rapidly acting cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation. Deslanoside inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations .

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Deslanoside Chemical Structure

Deslanoside Chemical Structure

CAS No. : 17598-65-1

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 364 In-stock
Estimated Time of Arrival: December 31
5 mg USD 210 In-stock
Estimated Time of Arrival: December 31
10 mg USD 350 In-stock
Estimated Time of Arrival: December 31
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100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Deslanoside (Desacetyllanatoside C) is a rapidly acting cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation. Deslanoside inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations [1][2][3].

In Vitro

Deslanoside (Desacetyllanatoside C) is a metabolite of Lanatoside C[4]. Deslanoside increases forearm blood flow and cardiac index and decreased heart rate concomitant with a marked decrease in skeletal muscle sympathetic nerve activity measured as an indicator of centrally mediated sympathetic nervous system activity[1].

Molecular Weight

943.08

Formula

C₄₇H₇₄O₁₉

CAS No.

17598-65-1

SMILES
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Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (106.04 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0604 mL 5.3018 mL 10.6036 mL
5 mM 0.2121 mL 1.0604 mL 2.1207 mL
10 mM 0.1060 mL 0.5302 mL 1.0604 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.65 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (2.65 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.65 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.76%

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Keywords:

DeslanosideDeacetyllanatoside CDesacetyllanatoside CNa+/K+ ATPaseDrug MetaboliteSodium potassium pumpcardiacglycosideheartfailuresupraventriculararrhythmiasrateInhibitorinhibitorinhibit

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Deslanoside
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