1. Apoptosis
    Anti-infection
  2. Apoptosis
    HIV
    Influenza Virus
  3. Psoralen

Psoralen (Synonyms: Ficusin)

Cat. No.: HY-N0053 Purity: 99.92%
Handling Instructions

Psoralen (Ficusin) is a coumarin isolated from the seeds of Fructus Psoraleae. Psoralen exhibits a wide range of biological properties, including anti-cancer, antioxidant, antidepressant, anticancer, antibacterial, and antiviral, et al.

For research use only. We do not sell to patients.

Psoralen Chemical Structure

Psoralen Chemical Structure

CAS No. : 66-97-7

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Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 73 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 73 In-stock
Estimated Time of Arrival: December 31
Solid
10 mg USD 66 In-stock
Estimated Time of Arrival: December 31
50 mg USD 235 In-stock
Estimated Time of Arrival: December 31
100 mg USD 362 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

Psoralen (Ficusin) is a coumarin isolated from the seeds of Fructus Psoraleae. Psoralen exhibits a wide range of biological properties, including anti-cancer, antioxidant, antidepressant, anticancer, antibacterial, and antiviral, et al[1].

In Vitro

Psoralen (10-500 μM; 24-48 hours) inhibits cell viability in a concentration- and time-dependent manner in L02 and HepG2 cells. In L02 cells, Psoralen at 400 μM does not significantly change extracellular LDH levels, and 400 μM or 450 μM psoralen inhibits 50–60% of cell viability[1].
Psoralen (150-450 μM; 24 hours) induces significant S-phase arrest in L02 cells in time- and dose-dependent manners, but it does not exhibits significant change in the cycle distribution of HepG2 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: L02 and HepG2 cells
Concentration: 10 μM, 50 μM,100 μM, 200 μM, 300 μM,400 μM,450 μM,500 μM
Incubation Time: 24 or 48 hours
Result: Inhibited the viability of L02 and HepG2 cells mainly by suppressing cell proliferation rather than causing cell death.

Cell Cycle Analysis[1]

Cell Line: L02 and HepG2 cells
Concentration: 150 μM; 300 μM; 450 μM
Incubation Time: 24 or 48 hours
Result: Induced cell S-phase arrest instead of causing cell apoptosis or death.
In Vivo

Psoralen (oral gavage; 17.5 mg/kg; 6 weeks) reduces the number of metastatic lesions and the rate of bone metastasis by 20% compared to vehicle-treated mice. It also reduces tumor infiltration and decreases the percentage of tumor cells in metastatic lesions by ~40% compared to vehicle in mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female nude (BALB/c nu/nu) mice[2]
Dosage: 17.5 mg/kg
Administration: Oral gavage; 17.5 mg/kg; 6 weeks
Result: Inhibited metastasis of breast cancer to bone in vivo.
Clinical Trial
Molecular Weight

186.16

Formula

C11H6O3

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (537.17 mM; Need ultrasonic)

H2O : 1 mg/mL (5.37 mM; ultrasonic and warming and heat to 80°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.3717 mL 26.8586 mL 53.7172 mL
5 mM 1.0743 mL 5.3717 mL 10.7434 mL
10 mM 0.5372 mL 2.6859 mL 5.3717 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (13.43 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (13.43 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (13.43 mM); Clear solution

*All of the co-solvents are available by MCE.
References

Purity: 99.92%

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Psoralen
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