90-45-9
90-45-9
Chemical Structure
9-Aminoacridine
Synonym(s): Aminacrine
- CAS No.: 90-45-9
- Formula:C13H10N2
- Molecular Weight:194.24
IUPAC Name: acridin-9-amine
InChIKey: XJGFWWJLMVZSIG-UHFFFAOYSA-N
SMILES: NC1=C(C=CC=C2)C2=NC3=CC=CC=C31
Biological Activity: 9-Aminoacridine, a fluorescent probe, acts as an indicator of pH for quantitative determination of transmembrane pH gradients (inside acidic). 9-Aminoacridine is an antimicrobial. 9-Aminoacridine exerts its antimicrobial activity by interacting with specific bacterial DNA and disrupting the proton motive force in K. pneumoniae. 9-Aminoacridine is a HIV-1 inhibitor and inhibits HIV LTR transcription highly dependent on the presence and location of the amino moiety. 9-Aminoacridine inhibits virus replication in HIV-1 infected cell lines. 9-Aminoacridine is used as a Rifampin (RIF; HY-B0272) adjuvant for the multidrug-resistant K. pneumoniae infections[1][2][3].
| Cat. No. | 상품명 | Purity | 제품 설명 | Pricing | |||||||||||||||||||
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9-Aminoacridine | 99.35% | 9-Aminoacridine, a fluorescent probe, acts as an indicator of pH for quantitative determination of transmembrane pH gradients (inside acidic). 9-Aminoacridine is an antimicrobial. 9-Aminoacridine exerts its antimicrobial activity by interacting with specific bacterial DNA and disrupting the proton motive force in K. pneumoniae. 9-Aminoacridine is a HIV-1 inhibitor and inhibits HIV LTR transcription highly dependent on the presence and location of the amino moiety. 9-Aminoacridine inhibits virus replication in HIV-1 infected cell lines. 9-Aminoacridine is used as a Rifampin (RIF; HY-B0272) adjuvant for the multidrug-resistant K. pneumoniae infections. | ||||||||||||||||||||
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9-Aminoacridine (Standard) | ≥98% | 9-Aminoacridine (Standard) is the analytical standard of 9-Aminoacridine. This product is intended for research and analytical applications. 9-Aminoacridine, a fluorescent probe, acts as an indicator of pH for quantitative determination of transmembrane pH gradients (inside acidic). 9-Aminoacridine is an antimicrobial. 9-Aminoacridine exerts its antimicrobial activity by interacting with specific bacterial DNA and disrupting the proton motive force in K. pneumoniae. 9-Aminoacridine is a HIV-1 inhibitor and inhibits HIV LTR transcription highly dependent on the presence and location of the amino moiety. 9-Aminoacridine inhibits virus replication in HIV-1 infected cell lines. 9-Aminoacridine is used as a Rifampin (RIF; HY-B0272) adjuvant for the multidrug-resistant K. pneumoniae infections. | ||||||||||||||||||||
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9-Aminoacridine-13C6 | 9-Aminoacridine-13C6 is the 13C-labeled 9-Aminoacridine(HY-B1422). 9-Aminoacridine, a fluorescent probe, acts as an indicator of pH for quantitative determination of transmembrane pH gradients (inside acidic). 9-Aminoacridine is an antimicrobial. 9-Aminoacridine exerts its antimicrobial activity by interacting with specific bacterial DNA and disrupting the proton motive force in K. pneumoniae. 9-Aminoacridine is a HIV-1 inhibitor and inhibits HIV LTR transcription highly dependent on the presence and location of the amino moiety. 9-Aminoacridine inhibits virus replication in HIV-1 infected cell lines. 9-Aminoacridine is used as a Rifampin (RIF; HY-B0272) adjuvant for the multidrug-resistant K. pneumoniae infections. | |||||||||||||||||||||
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1-Aminoacridine | 1-Aminoacridine (1-Acridinamine) is a bright fluorescent dye. 1-Aminoacridine acts as an anti-infective agent and mutagen due to its ability to interact with DNA. | |||||||||||||||||||||
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6-Aminophenanthridine | 6-Aminophenanthridine inhibits the protein folding activity of the ribosome (PFAR). 6-Aminophenanthridine competitively occludes the protein substrates from binding to rRNA and thereby inhibits PFAR. | |||||||||||||||||||||
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Thio-acridone | Thio-acridone (SACD) is a photosensitizer (HAF-PSs). Thio-acridone forms a long-lived triplet state upon excitation by 470 nm visible light,, ultimately generating singlet oxygen to damage the structures and functions of target cells such as cancer cells. Thio-acridone is promising for research of cancers. Thio-acridone is a CDK4/Cyclin D1 inhibitor (IC50 = 2 uM). | |||||||||||||||||||||
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9-Aminophenanthrene | 99.74% | 9-Aminophenanthrene is a type of polycyclic aromatic amine compound, which can be used as a fluorescent labeling reagent for free fatty acids (FFA). | ||||||||||||||||||||
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Acridone | 99.89% | Acridone is an organic compound based on the acridine skeleton. Acridone has antibacterial, antimalarial, antiviral and anti neoplastic activities. | ||||||||||||||||||||
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9-Methylacridine (Standard) | ≥98% | 9-Methylacridine (Standard) is the analytical standard of 9-Methylacridine. This product is intended for research and analytical applications. | ||||||||||||||||||||
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Phenazine | 99.94% | Phenazine belongs to the family of N-heterocyclic compounds. Phenazine can be found in terrestrial and marine microorganisms. Phenazine attracts attention due to its diverse biological activities, including Antimicrobial and enzyme inhibitory properties. Phenazine can be used in breast cancer research. | ||||||||||||||||||||
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9-Anthracenamine | 9-anthracenamine is an end-capping agent. 9-anthracenamine caps both ends of polyrotaxanes and free PPG chains to avoid dethreading. | |||||||||||||||||||||
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Phenanthridine | Phenanthridine is an aldehyde oxidase 1 (AOX1) substrate, with oxidation by hAOX1 yielding phenanthridone when molecular oxygen, ferricyanide, or dichlorophenolindophenol serves as electron acceptor. | |||||||||||||||||||||
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References
- [1]. S Grzesiek, et al. The 'delta pH'-probe 9-aminoacridine: response time, binding behaviour and dimerization at the membrane. Biochim Biophys Acta. 1988 Mar 3;938(3):411-24. [Content Brief]
- [2]. Pengfei She, et al. Repurposing 9-Aminoacridine as an Adjuvant Enhances the Antimicrobial Effects of Rifampin against Multidrug-Resistant Klebsiella pneumonia. Microbiol Spectr. 2023 Jun 15;11(3):e0447422. [Content Brief]
- [3]. Irene Guendel, et al. 9-Aminoacridine inhibition of HIV-1 Tat dependent transcription. Virol J. 2009 Jul 24:6:114. [Content Brief]
