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Cat. No.: HY-135189

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6-Aminophenanthridine

6-Aminophenanthridine inhibits the protein folding activity of the ribosome (PFAR). 6-Aminophenanthridine competitively occludes the protein substrates from binding to rRNA and thereby inhibits PFAR.

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CAS No.: 832-68-8
Formule: C₁₃H₁₀N₂
Masse moléculaire:194.23

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

6-Aminophenanthridine Chemical Structure

CAS No.: 832-68-8

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Activité biologique
- Description
- Cellular Effect
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Activité biologique

Description

6-Aminophenanthridine inhibits the protein folding activity of the ribosome (PFAR). 6-Aminophenanthridine competitively occludes the protein substrates from binding to rRNA and thereby inhibits PFAR^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	CC₅₀	30.53 μM Compound: PA-01	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by alamar blue assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by alamar blue assay	[PMID: 37593576]
HepG2	EC₅₀	<30 μM Compound: 51	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 37976706]
HepG2	EC₅₀	3.07 μM Compound: 51	Cytotoxicity against human HepG2 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay	[PMID: 37976706]
HepG2	EC₅₀	3.07 μM Compound: 85	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 37421889]

Chemical Information

CAS No. 832-68-8
Masse moléculaire 194.23
Formule C₁₃H₁₀N₂
SMILES

NC1=C2C=CC=CC2=C(C=CC=C3)C3=N1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Pang Y, et al. The antiprion compound 6-aminophenanthridine inhibits the protein folding activity of the ribosome by direct competition. J Biol Chem. 2013;288(26):19081-19089. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
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Chemical Information
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6-Aminophenanthridine

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6-Aminophenanthridine Related Classifications

HY-135189 Related Classifications