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  4. 6-Aminophenanthridine

6-Aminophenanthridine inhibits the protein folding activity of the ribosome (PFAR). 6-Aminophenanthridine competitively occludes the protein substrates from binding to rRNA and thereby inhibits PFAR.

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6-Aminophenanthridine

6-Aminophenanthridine Chemical Structure

CAS No. : 832-68-8

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Based on 1 publication(s) in Google Scholar

6-Aminophenanthridine Related Antibodies

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Description

6-Aminophenanthridine inhibits the protein folding activity of the ribosome (PFAR). 6-Aminophenanthridine competitively occludes the protein substrates from binding to rRNA and thereby inhibits PFAR[1].

Cellular Effect
Cell Line Type Value Description References
HepG2 CC50
30.53 μM
Compound: PA-01
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by alamar blue assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by alamar blue assay
[PMID: 37593576]
HepG2 EC50
3.07 μM
Compound: 51
Cytotoxicity against human HepG2 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
[PMID: 37976706]
HepG2 EC50
3.07 μM
Compound: 85
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 37421889]
HepG2 EC50
< 30 μM
Compound: 51
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 37976706]
Molecular Weight

194.23

Formula

C13H10N2
CAS No.
SMILES

NC1=C2C=CC=CC2=C(C=CC=C3)C3=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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6-Aminophenanthridine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

6-Aminophenanthridine832-68-8Othersprotein folding activityPFARrRNAribosomeInhibitorinhibitorinhibit

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HY-135189
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