1. Anti-infection
    Membrane Transporter/Ion Channel
    Autophagy
  2. Bacterial
    Potassium Channel
    Autophagy
  3. Proflavine hemisulfate

Proflavine hemisulfate (Synonyms: Proflavin hemisulfate; 3,6-Diaminoacridine hemisulfate)

Cat. No.: HY-B0883 Purity: 98.17%
Handling Instructions

Proflavine hemisulfate, an acridine dye, is a known DNA intercalating agent. Anti-microbial agent. Proflavine hemisulfate behaves as a pore blocker for Kir3.2. Proflavine hemisulfate is a potential lead compound for Kir3.2-associated neurological diseases.

For research use only. We do not sell to patients.

Proflavine hemisulfate Chemical Structure

Proflavine hemisulfate Chemical Structure

CAS No. : 1811-28-5

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Estimated Time of Arrival: December 31
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Description

Proflavine hemisulfate, an acridine dye, is a known DNA intercalating agent. Anti-microbial agent[1]. Proflavine hemisulfate behaves as a pore blocker for Kir3.2. Proflavine hemisulfate is a potential lead compound for Kir3.2-associated neurological diseases[2].

In Vitro

Proflavine (0.1-10 μM; 24 hours) inhibits the growth of Kir3.2-transformant cells and Kir3.2 activity in a concentration-dependent manner[1].
Proflavine (300 μM) progressively reduces the current amplitude of Kir3.2 mutant to 27.7±4.3% of the control[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: Kir3.2*-transformant BYT123 cells
Concentration: 0.1, 1, and 10 μM
Incubation Time: 24 hours
Result: Dose-dependent inhibition of the growth of Kir3.2*-transformant cells.
Attenuated the growth of Kir3.2*-transformant cells without affecting the growth of control cells.
In Vivo

The concentrations of Proflavine (20 mg/kg) in whole blood after intravenous injection decreased rapidly at the beginning and remained stable from around 30 min after dosing[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague Dawley rats (weighing approximately 200 g)[3]
Dosage: 20 mg/kg (Pharmacokinetic Analysis)
Administration: Intravenous injection; 2, 4, 5, 10, 15, 20, 25, and 30 min after dosing
Result: Concentration decreased rapidly from whole blood in the first 5 min after dosing, followed by a slower decrease.
Clinical Trial
Molecular Weight

258.29

Formula

C₁₃H₁₁N₃ . ₁/₂ H₂O₄S

CAS No.
SMILES

NC1=CC2=NC3=CC(N)=CC=C3C=C2C=C1.[0.5H2SO4]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 5 mg/mL (19.36 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8716 mL 19.3581 mL 38.7162 mL
5 mM 0.7743 mL 3.8716 mL 7.7432 mL
10 mM 0.3872 mL 1.9358 mL 3.8716 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

Proflavine hemisulfateProflavin hemisulfate 3,6-Diaminoacridine hemisulfateBacterialPotassium ChannelAutophagyKcsAWholebloodG proteingatedinwardrectifierK+channelInhibitorinhibitorinhibit

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Proflavine hemisulfate
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