2. Anti-infection Membrane Transporter/Ion Channel Autophagy
  3. Bacterial Potassium Channel Autophagy
  4. Proflavine hemisulfate

Proflavine hemisulfate  (Synonyms: Proflavin hemisulfate; 3,6-Diaminoacridine hemisulfate)

Cat. No.: HY-B0883 Purity: 98.45%
COA Handling Instructions

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Proflavine hemisulfate, an acridine dye, is a known DNA intercalating agent. Anti-microbial agent. Proflavine hemisulfate behaves as a pore blocker for Kir3.2. Proflavine hemisulfate is a potential lead compound for Kir3.2-associated neurological diseases.

For research use only. We do not sell to patients.

Proflavine hemisulfate Chemical Structure

Proflavine hemisulfate Chemical Structure

CAS No. : 1811-28-5

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 66 In-stock
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10 mM * 1 mL in Water USD 66 In-stock
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Based on 2 publication(s) in Google Scholar

Other Forms of Proflavine hemisulfate:

Proflavine hemisulfate Related Antibodies

Top Publications Citing Use of Products

2 Publications Citing Use of MCE Proflavine hemisulfate

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Proflavine hemisulfate, an acridine dye, is a known DNA intercalating agent. Anti-microbial agent[1]. Proflavine hemisulfate behaves as a pore blocker for Kir3.2. Proflavine hemisulfate is a potential lead compound for Kir3.2-associated neurological diseases[2].

In Vitro

Proflavine (0.1-10 μM; 24 hours) inhibits the growth of Kir3.2-transformant cells and Kir3.2 activity in a concentration-dependent manner[1].
Proflavine (300 μM) progressively reduces the current amplitude of Kir3.2 mutant to 27.7±4.3% of the control[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Proflavine hemisulfate Related Antibodies

Cell Viability Assay[2]

Cell Line: Kir3.2*-transformant BYT123 cells
Concentration: 0.1, 1, and 10 μM
Incubation Time: 24 hours
Result: Dose-dependent inhibition of the growth of Kir3.2*-transformant cells.
Attenuated the growth of Kir3.2*-transformant cells without affecting the growth of control cells.
In Vivo

The concentrations of Proflavine (20 mg/kg) in whole blood after intravenous injection decreased rapidly at the beginning and remained stable from around 30 min after dosing[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague Dawley rats (weighing approximately 200 g)[3]
Dosage: 20 mg/kg (Pharmacokinetic Analysis)
Administration: Intravenous injection; 2, 4, 5, 10, 15, 20, 25, and 30 min after dosing
Result: Concentration decreased rapidly from whole blood in the first 5 min after dosing, followed by a slower decrease.
Clinical Trial
Molecular Weight

258.28

Formula

C13H11N3.1/2H2SO4
CAS No.
Appearance

Solid

Color

Brown to reddish brown

SMILES

NC1=CC2=NC3=CC(N)=CC=C3C=C2C=C1.[0.5H2SO4]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 16.67 mg/mL (64.54 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : ≥ 5 mg/mL (19.36 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8718 mL 19.3588 mL 38.7177 mL
5 mM 0.7744 mL 3.8718 mL 7.7435 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.45%

COA (248 KB) LCMS (86 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 3.8718 mL 19.3588 mL 38.7177 mL 96.7942 mL
5 mM 0.7744 mL 3.8718 mL 7.7435 mL 19.3588 mL
10 mM 0.3872 mL 1.9359 mL 3.8718 mL 9.6794 mL
15 mM 0.2581 mL 1.2906 mL 2.5812 mL 6.4529 mL
DMSO 20 mM 0.1936 mL 0.9679 mL 1.9359 mL 4.8397 mL
25 mM 0.1549 mL 0.7744 mL 1.5487 mL 3.8718 mL
30 mM 0.1291 mL 0.6453 mL 1.2906 mL 3.2265 mL
40 mM 0.0968 mL 0.4840 mL 0.9679 mL 2.4199 mL
50 mM 0.0774 mL 0.3872 mL 0.7744 mL 1.9359 mL
60 mM 0.0645 mL 0.3226 mL 0.6453 mL 1.6132 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Proflavine hemisulfate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Proflavine hemisulfate1811-28-5Proflavin hemisulfate 3,6-Diaminoacridine hemisulfateBacterialPotassium ChannelAutophagyKcsAWholebloodG proteingatedinwardrectifierK+channelInhibitorinhibitorinhibit

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