1. Steroids
  2. Daucosterol

Daucosterol (Synonyms: Eleutheroside A; β-Sitosterol β-D-glucoside)

Cat. No.: HY-N0410
Handling Instructions

Daucosterol is a natural sterolin.

For research use only. We do not sell to patients.

Daucosterol Chemical Structure

Daucosterol Chemical Structure

CAS No. : 474-58-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 107 In-stock
Estimated Time of Arrival: December 31
5 mg USD 84 In-stock
Estimated Time of Arrival: December 31
10 mg USD 132 In-stock
Estimated Time of Arrival: December 31
25 mg USD 264 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Top Publications Citing Use of Products

    Daucosterol purchased from MCE. Usage Cited in: Eur J Pharmacol. 2019 Apr. 

    Western blot analysis of p53 expression and phosphorylation in DS treated A549 cells with the indicated concentrations after 72 h incubation. DS up-regulates p53 expression and phosphorylation which resulted in activation of downstream regulator p21.
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    Description

    Daucosterol is a natural sterolin. IC50 value: Target: In vitro: In the study of the effects of daucosterol on the survival of cultured cortical neurons after neurons were subjected to oxygen and glucose deprivation and simulated reperfusion (OGD/R)(2), the results showed that post-treatment of daucosterol significantly reduced neuronal loss, as well as apoptotic rate and caspase-3 activity, displaying the neuroprotective activity. We also found that daucosterol increased the expression level of IGF1 protein, diminished the down-regulation of p-AKT(3) and p-GSK-3β(4), thus activating the AKT(5) signal pathway [1]. Cell counting kit-8 (CCK-8) assay showed that daucosterol significantly increased the quantity of viable cells and the effectiveness of daucosterol was similar to that of basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF) [2]. Daucosterol inhibits the proliferation of human breast cancer cell line MCF-7 and gastric cancer cell lines MGC803, BGC823 and AGS in a dose-dependent manner. Furthermore, daucosterol inhibits murine hepatoma H22 cell growth in ICR mice. Daucosterol treatment induces intracellular ROS generation and autophagy, but not apoptotic cell death. Treatment with ROS scavenger GSH (reduced glutathione), NAC (N-acetyl-l-cysteine) or autophagy inhibitor 3-Methyladenine (3-MA) counteracted daucosterol-induced autophagy and growth inhibition in BGC823 and MCF-7 cancer cells [3]. In vivo:

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 7.9 mg/mL (13.70 mM; Need ultrasonic and warming)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.7336 mL 8.6678 mL 17.3355 mL
    5 mM 0.3467 mL 1.7336 mL 3.4671 mL
    10 mM 0.1734 mL 0.8668 mL 1.7336 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    576.85

    Formula

    C₃₅H₆₀O₆

    CAS No.

    474-58-8

    SMILES
    Shipping

    Room temperature in continental US; may vary elsewhere

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    Product Name:
    Daucosterol
    Cat. No.:
    HY-N0410
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    Daucosterol

    Cat. No.: HY-N0410