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  5. Daucosterol

Daucosterol  (Synonyms: Eleutheroside A; β-Sitosterol β-D-glucoside)

Cat. No.: HY-N0410 Purity: ≥80.0%
COA Handling Instructions

Daucosterol is a natural sterolin.

For research use only. We do not sell to patients.

Daucosterol Chemical Structure

Daucosterol Chemical Structure

CAS No. : 474-58-8

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5 mg USD 84 In-stock
Estimated Time of Arrival: December 31
10 mg USD 132 In-stock
Estimated Time of Arrival: December 31
25 mg USD 264 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 4 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Daucosterol purchased from MCE. Usage Cited in: Eur J Pharmacol. 2019 Jul 15;855:112-123.  [Abstract]

    Western blot analysis of p53 expression and phosphorylation in DS treated A549 cells with the indicated concentrations after 72 h incubation. DS up-regulates p53 expression and phosphorylation which resulted in activation of downstream regulator p21.
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    Daucosterol is a natural sterolin. IC50 value: Target: In vitro: In the study of the effects of daucosterol on the survival of cultured cortical neurons after neurons were subjected to oxygen and glucose deprivation and simulated reperfusion (OGD/R)(2), the results showed that post-treatment of daucosterol significantly reduced neuronal loss, as well as apoptotic rate and caspase-3 activity, displaying the neuroprotective activity. We also found that daucosterol increased the expression level of IGF1 protein, diminished the down-regulation of p-AKT(3) and p-GSK-3β(4), thus activating the AKT(5) signal pathway [1]. Cell counting kit-8 (CCK-8) assay showed that daucosterol significantly increased the quantity of viable cells and the effectiveness of daucosterol was similar to that of basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF) [2]. Daucosterol inhibits the proliferation of human breast cancer cell line MCF-7 and gastric cancer cell lines MGC803, BGC823 and AGS in a dose-dependent manner. Furthermore, daucosterol inhibits murine hepatoma H22 cell growth in ICR mice. Daucosterol treatment induces intracellular ROS generation and autophagy, but not apoptotic cell death. Treatment with ROS scavenger GSH (reduced glutathione), NAC (N-acetyl-l-cysteine) or autophagy inhibitor 3-Methyladenine (3-MA) counteracted daucosterol-induced autophagy and growth inhibition in BGC823 and MCF-7 cancer cells [3]. In vivo:

    Molecular Weight




    CAS No.
    Structure Classification

    Room temperature in continental US; may vary elsewhere.

    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 3.33 mg/mL (5.77 mM; Need ultrasonic)

    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.7336 mL 8.6678 mL 17.3355 mL
    5 mM 0.3467 mL 1.7336 mL 3.4671 mL
    10 mM --- --- ---
    *Please refer to the solubility information to select the appropriate solvent.
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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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