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Fargesone A

Fargesone A is a potent and selective FXR agonist. Fargesone A shows anti-inflammatory activity.

For research use only. We do not sell to patients.

CAS No.: 116424-69-2
Formula: C₂₁H₂₄O₆
Molecular Weight:372.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

Fargesone A Chemical Structure

CAS No.: 116424-69-2

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Sample (0.1mg)

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(In Japan)

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

Fargesone A is a potent and selective FXR agonist. Fargesone A shows anti-inflammatory activity^[1].

IC₅₀ & Target

FXR^[1]

In Vitro

Fargesone A (10 μM; 24 h) alleviates hepatocyte disorders in an FXR-dependent manner in human liver WRL68 cells^[1].
Agonistic activity of Fargesone A is through direct interaction with FXR^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Fargesone A (3 and 30 mg/kg; i.p.; daily for 7 days) significantly ameliorates pathological features in bile duct ligation (BDL)-induced chronic liver fibrosis mouse model^[1].
Pharmacokinetics parameters of Fargesone A in mice

	t_1/2 (h)	T_max (h)	C_max (ng/mL)	AUC_0-t (ng/mL*h)	AUC_0-inf (ng/mL*h)	MRT_0-inf (h)	F (%)
i.v. (5 mpk)	0.68±0.1	-	941±57	469±13	471±14	0.43±0.13	-
p.o. (10 mpk)	0.33±0.04	0.25±0.00	104±16	101±32	102±32	0.58±0.07	10.8±3.2

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6 mice, bile duct ligation (BDL)-induced chronic liver fibrosis mouse model^[1]
Dosage:

3 and 30 mg/kg
Administration:

IP, once daily for 7 days
Result:

Resulted in a lower level of inflammatory infiltrates and a smaller amount of collagen deposition compared to the vehicle group. Reversed BDL-induced sharp increase in total bilirubin level in the serum. Significantly decreased liver mRNA expression of the inflammatory biomarkers interleukin (IL)-6, IL-1β, inducible nitric oxide synthase (iNOS), and prostaglandin-endoperoxide synthase 2 (COX2).

Animal Model:

C57BL6/J mice^[1]
Dosage:

5 or 10 mg/kg
Administration:

IV or PO (Pharmacokinetics Analysis)
Result:

Showed acceptable PK profiles in general.

Chemical Information

CAS No. 116424-69-2
Molecular Weight 372.41
Formula C₂₁H₂₄O₆
SMILES

CO[C@@]12[C@@](O[C@@H](C3=CC=C(OCO4)C4=C3)[C@@H]2C)([H])[C@@H](C(C=C1OC)=O)CC=C
Structure Classification
- Phenylpropanoids
- Lignans
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Guo F, et al. Biomimetic Total Synthesis and the Biological Evaluation of Natural Product (-)-Fargesone A as a Novel FXR Agonist. JACS Au. 2022 Dec 7;2(12):2830-2838. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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