1. Metabolic Enzyme/Protease
  2. FXR
  3. Fargesone A

Fargesone A 

Cat. No.: HY-N3891
Handling Instructions

Fargesone A is a potent and selective FXR agonist. Fargesone A shows anti-inflammatory activity.

For research use only. We do not sell to patients.

Fargesone A Chemical Structure

Fargesone A Chemical Structure

CAS No. : 116424-69-2

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Fargesone A is a potent and selective FXR agonist. Fargesone A shows anti-inflammatory activity[1].

IC50 & Target

FXR[1]

In Vitro

Fargesone A (10 μM; 24 h) alleviates hepatocyte disorders in an FXR-dependent manner in human liver WRL68 cells[1].
Agonistic activity of Fargesone A is through direct interaction with FXR[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Fargesone A (3 and 30 mg/kg; i.p.; daily for 7 days) significantly ameliorates pathological features in bile duct ligation (BDL)-induced chronic liver fibrosis mouse model[1].
Pharmacokinetics parameters of Fargesone A in mice

t1/2 (h) Tmax (h) Cmax (ng/mL) AUC0-t (ng/mL*h) AUC0-inf (ng/mL*h) MRT0-inf (h) F (%)
i.v. (5 mpk) 0.68±0.1 - 941±57 469±13 471±14 0.43±0.13 -
p.o. (10 mpk) 0.33±0.04 0.25±0.00 104±16 101±32 102±32 0.58±0.07 10.8±3.2

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice, bile duct ligation (BDL)-induced chronic liver fibrosis mouse model[1]
Dosage: 3 and 30 mg/kg
Administration: IP, once daily for 7 days
Result: Resulted in a lower level of inflammatory infiltrates and a smaller amount of collagen deposition compared to the vehicle group. Reversed BDL-induced sharp increase in total bilirubin level in the serum. Significantly decreased liver mRNA expression of the inflammatory biomarkers interleukin (IL)-6, IL-1β, inducible nitric oxide synthase (iNOS), and prostaglandin-endoperoxide synthase 2 (COX2).
Animal Model: C57BL6/J mice[1]
Dosage: 5 or 10 mg/kg
Administration: IV or PO (Pharmacokinetics Analysis)
Result: Showed acceptable PK profiles in general.
Molecular Weight

372.41

Formula

C21H24O6

CAS No.
SMILES

CO[C@@]12[C@@](O[C@@H](C3=CC=C(OCO4)C4=C3)[C@@H]2C)([H])[C@@H](C(C=C1OC)=O)CC=C

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Fargesone A Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Fargesone A
Cat. No.:
HY-N3891
Quantity:
MCE Japan Authorized Agent: