1. Immunology/Inflammation
    NF-κB
    Metabolic Enzyme/Protease
  2. Reactive Oxygen Species
  3. Maresin 1

Maresin 1 

Cat. No.: HY-116429
Handling Instructions

Maresin 1, produced by human Mφs from endogenous docosahexaenoic acid (DHA) and a specialized proresolving mediator, stimulates intracellular [Ca2+] and secretion. Maresin 1 possesses anti-inflammatory activity.

For research use only. We do not sell to patients.

Maresin 1 Chemical Structure

Maresin 1 Chemical Structure

CAS No. : 1268720-28-0

Size Price Stock
50 μg USD 950 Ask For Quote & Lead Time
100 μg USD 1500 Ask For Quote & Lead Time

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Maresin 1, produced by human Mφs from endogenous docosahexaenoic acid (DHA) and a specialized proresolving mediator, stimulates intracellular [Ca2+] and secretion. Maresin 1 possesses anti-inflammatory activity[1][2][3].

In Vitro

Maresin 1 (MaR1, 300 nM) reduces neutrophil migration and reactive oxygen species production, besides decreasing IL-1b, TNF-a, IL-6, and INF-g production[3].

Cell Viability Assay[3]

Cell Line: Neutrophils (2 ╳105 cells/well).
Concentration: 300 nM.
Incubation Time: 30 min.
Result: Adherent cells are stimulated for 24 h with LPS (1 mg/ml) in the presence or absence of MaR1 (300 nM) in a final volume of 250 ml/well[3].
In Vivo

Maresin 1 (MaR1) dose-dependently inhibits TRPV1 currents in neurons, blocks capsaicin (100 nM)-induced inward currents (IC50=0.49 nM), and reduces both inflammation- and chemotherapy-induced neuropathic pain in mice[2].
Maresin 1 (MaR1, 0.1, 0.3, and 1 μg/animal, e.v.) protects mice against acute DSS-induced colitis. Maresin 1 (0.3, and 1 μg/animal, e.v.) treatment markedly reduces macroscopic damage in the acute protocol of DSS-induced colitis[3].

Animal Model: Male CD1 mice (8-10 wk of age) (colitis was induced by DSS)[3].
Dosage: 0.1, 0.3, and 1 μg/animal.
Administration: Intraocular route once a day from day 0 to day 7.
Result: MaR1 (0.3 and 1 mg/animal) significantly reduces MPO levels in mouse colon tissue.
Molecular Weight

360.49

Formula

C₂₂H₃₂O₄

CAS No.

1268720-28-0

SMILES

CC/C=C\C/C=C\C[[email protected]](O)/C=C\C=C\C=C\[[email protected]](O)C/C=C\CCC(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Maresin 1Maresin1Maresin-1Reactive Oxygen SpeciesROSLPSCa2+Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Maresin 1
Cat. No.:
HY-116429
Quantity:
MCE Japan Authorized Agent: