2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species
  4. Maresin 1

Maresin 1, produced by human Mφs from endogenous docosahexaenoic acid (DHA) and a specialized proresolving mediator, stimulates intracellular [Ca2+] and secretion. Maresin 1 possesses anti-inflammatory activity.

For research use only. We do not sell to patients.

Maresin 1 Chemical Structure

Maresin 1 Chemical Structure

CAS No. : 1268720-28-0

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Solvent
10 μg (277.4 µM * 100 μL in Ethanol) USD 230 In-stock
Solvent
25 μg (277.4 µM * 250 μL in Ethanol) USD 485 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Maresin 1:

Maresin 1 Related Antibodies

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1 Publications Citing Use of MCE Maresin 1

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Description

Maresin 1, produced by human Mφs from endogenous docosahexaenoic acid (DHA) and a specialized proresolving mediator, stimulates intracellular [Ca2+] and secretion. Maresin 1 possesses anti-inflammatory activity[1][2][3].

In Vitro

Maresin 1 (MaR1, 300 nM) reduces neutrophil migration and reactive oxygen species production, besides decreasing IL-1b, TNF-a, IL-6, and INF-g production[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Maresin 1 Related Antibodies

Cell Viability Assay[3]

Cell Line: Neutrophils (2 ╳105 cells/well).
Concentration: 300 nM.
Incubation Time: 30 min.
Result: Adherent cells are stimulated for 24 h with LPS (1 mg/ml) in the presence or absence of MaR1 (300 nM) in a final volume of 250 ml/well[3].
In Vivo

Maresin 1 (MaR1) dose-dependently inhibits TRPV1 currents in neurons, blocks capsaicin (100 nM)-induced inward currents (IC50=0.49 nM), and reduces both inflammation- and chemotherapy-induced neuropathic pain in mice[2].
Maresin 1 (MaR1, 0.1, 0.3, and 1 μg/animal, e.v.) protects mice against acute DSS-induced colitis. Maresin 1 (0.3, and 1 μg/animal, e.v.) treatment markedly reduces macroscopic damage in the acute protocol of DSS-induced colitis[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male CD1 mice (8-10 wk of age) (colitis was induced by DSS)[3].
Dosage: 0.1, 0.3, and 1 μg/animal.
Administration: Intraocular route once a day from day 0 to day 7.
Result: MaR1 (0.3 and 1 mg/animal) significantly reduces MPO levels in mouse colon tissue.
Molecular Weight

360.49

Formula

C22H32O4
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

CC/C=C\C/C=C\C[C@H](O)/C=C\C=C\C=C\[C@H](O)C/C=C\CCC(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years
Purity & Documentation

Purity: ≥99.0%

COA (238 KB)

Handling Instructions (2659 KB)
References
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Maresin 1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Maresin 11268720-28-0Maresin1Maresin-1Reactive Oxygen SpeciesROSLPSCa2+Inhibitorinhibitorinhibit

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HY-116429
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