1,3,5-Trihydroxy-4-prenylxanthone

Cat. No.: HY-N10156: Data Sheet Handling Instructions
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1,3,5-Trihydroxy-4-prenylxanthone is a Na⁺/H⁺ exchange system inhibitor with a minimum inhibitory concentration of 10 μg/mL. 1,3,5-Trihydroxy-4-prenylxanthone is a phosphodiesterase type 5 (PDE5) inhibitor with an IC₅₀ value of 3.0 μM. 1,3,5-Trihydroxy-4-prenylxanthone inhibits Lipopolysaccharide (LPS) (HY-D1056)-induced NO production in RAW264.7 macrophages, and has anti-inflammatory activities.

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1,3,5-Trihydroxy-4-prenylxanthone 화학구조

CAS No. : 53377-61-0

사이즈		재고
MOQ		Minimum order quantity
50 mg		견적 받기
100 mg		견적 받기
250 mg		견적 받기
Other size		견적 받기

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This product is a controlled substance and not for sale in your territory.

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•Related Small Molecules:

•Related Proteins:

View All Phosphodiesterase (PDE) Isoform Specific Products:

View All Isoforms

PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

View All NO Synthase Isoform Specific Products:

View All Isoforms

nNOS iNOS eNOS

Biological Activity
순도&문서
References
고객리뷰

제품 설명

1,3,5-Trihydroxy-4-prenylxanthone is a Na⁺/H⁺ exchange system inhibitor with a minimum inhibitory concentration of 10 μg/mL^[1]. 1,3,5-Trihydroxy-4-prenylxanthone is a phosphodiesterase type 5 (PDE5) inhibitor with an IC₅₀ value of 3.0 μM^[3]. 1,3,5-Trihydroxy-4-prenylxanthone inhibits Lipopolysaccharide (LPS) (HY-D1056)-induced NO production in RAW264.7 macrophages, and has anti-inflammatory activities^[2].

IC₅₀ & Target^[1]^[2]^[3]

PDE5

3 μM (IC₅₀)

iNOS

Na+/H+ Exchanger

Cellular Effect

Cell Line	Type	Value	Description	References
HSC-T6	IC₅₀	> 30 μM Compound: 11	Antiproliferative activity against rat HSC-T6 cells assessed as reduction in cell viability Antiproliferative activity against rat HSC-T6 cells assessed as reduction in cell viability	[PMID: 25322455]

In Vitro

1,3,5-Trihydroxy-4-prenylxanthone (10-30 μM; 18 hours) shows a suppression of LPS-induced iNOS expression through abolishing IKK phosphorylation, IκB degradation and NF-κB nuclear translocation. 1,3,5-Trihydroxy-4-prenylxanthone inhibits LPS-induced iNOS expression by interference with the posttranslational modification of IRAK-1 resulted in blocking TAK1-mediated activation of IKK and MAPKs signal transduction to down-regulate NF-κB and AP-1 activation^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2]

Cell Line:	RAW264.7 macrophages
Concentration:	10 μM, 20 μM and 30 μM
Incubation Time:	18 hours
Result:	Showed suppression of LPS-induced iNOS expression. Suppressed the nuclear level of c-Fos and c-Jun (major components of activator protein-1, AP-1) and the phosphorylated level of upstream signal molecules, such as JNK and ERK.

분자량

312.32

화학식

C₁₈H₁₆O₅

CAS No.

53377-61-0

SMILES

C/C(C)=C\CC1=C2C(C(C3=C(C(O)=CC=C3)O2)=O)=C(O)C=C1O

Structure Classification

Initial Source

선적

Room temperature in continental US; may vary elsewhere.

보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. [1] M Kobayashi, et al. Indonesian medicinal plants. XXI. Inhibitors of Na+/H+ exchanger from the bark of Erythrina variegata and the roots of Maclura cochinchinensis. Chem Pharm Bull (Tokyo). 1997 Oct;45(10):1615-9. [Content Brief]

[2]. Wen-Fei Chiou, et al. 1,3,5-trihydroxy-4-prenylxanthone represses lipopolysaccharide-induced iNOS expression via impeding posttranslational modification of IRAK-1. Biochem Pharmacol. 2011 Mar 15;81(6):752-60. [Content Brief]

[3]. Chalisa Sabphon, et al. Phosphodiesterase inhibitory activity of the flavonoids and xanthones from Anaxagorea luzonensis. Nat Prod Commun. 2015 Feb;10(2):301-3. [Content Brief]