1,3,5-Trihydroxy-4-prenylxanthone
1,3,5-Trihydroxy-4-prenylxanthone is a Na+/H+ exchange system inhibitor with a minimum inhibitory concentration of 10 μg/mL. 1,3,5-Trihydroxy-4-prenylxanthone is a phosphodiesterase type 5 (PDE5) inhibitor with an IC50 value of 3.0 μM. 1,3,5-Trihydroxy-4-prenylxanthone inhibits Lipopolysaccharide (LPS) (HY-D1056)-induced NO production in RAW264.7 macrophages, and has anti-inflammatory activities.
For research use only. We do not sell to patients.
- CAS No.: 53377-61-0
- Formula: C18H16O5
- Molecular Weight:312.32
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PDE5 3 μM (IC50) |
iNOS |
Na+/H+ Exchanger |
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Cell Line
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Type | Value | Description | References |
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| HSC-T6 | IC50 |
>30 μM
Compound: 11
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Antiproliferative activity against rat HSC-T6 cells assessed as reduction in cell viability
Antiproliferative activity against rat HSC-T6 cells assessed as reduction in cell viability
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[PMID: 25322455] |
1,3,5-Trihydroxy-4-prenylxanthone (10-30 μM; 18 hours) shows a suppression of LPS-induced iNOS expression through abolishing IKK phosphorylation, IκB degradation and NF-κB nuclear translocation. 1,3,5-Trihydroxy-4-prenylxanthone inhibits LPS-induced iNOS expression by interference with the posttranslational modification of IRAK-1 resulted in blocking TAK1-mediated activation of IKK and MAPKs signal transduction to down-regulate NF-κB and AP-1 activation[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW264.7 macrophages
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Concentration:10 μM, 20 μM and 30 μM
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Incubation Time:18 hours
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Result:Showed suppression of LPS-induced iNOS expression. Suppressed the nuclear level of c-Fos and c-Jun (major components of activator protein-1, AP-1) and the phosphorylated level of upstream signal molecules, such as JNK and ERK.
Chemical Information
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CAS No. 53377-61-0
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Molecular Weight 312.32
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Formula C18H16O5
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SMILES
C/C(C)=C\CC1=C2C(C(C3=C(C(O)=CC=C3)O2)=O)=C(O)C=C1O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. [1] M Kobayashi, et al. Indonesian medicinal plants. XXI. Inhibitors of Na+/H+ exchanger from the bark of Erythrina variegata and the roots of Maclura cochinchinensis. Chem Pharm Bull (Tokyo). 1997 Oct;45(10):1615-9. [Content Brief]
[2]. Wen-Fei Chiou, et al. 1,3,5-trihydroxy-4-prenylxanthone represses lipopolysaccharide-induced iNOS expression via impeding posttranslational modification of IRAK-1. Biochem Pharmacol. 2011 Mar 15;81(6):752-60. [Content Brief]
[3]. Chalisa Sabphon, et al. Phosphodiesterase inhibitory activity of the flavonoids and xanthones from Anaxagorea luzonensis. Nat Prod Commun. 2015 Feb;10(2):301-3. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
1,3,5-Trihydroxy-4-prenylxanthone Related Classifications
HY-N10156 Related Classifications
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