53377-61-0
Chemical Structure
1,3,5-Trihydroxy-4-prenylxanthone
- CAS No.: 53377-61-0
- Formula:C18H16O5
- Molecular Weight:312.32
IUPAC Name: 1,3,5-trihydroxy-4-(3-methylbut-2-en-1-yl)-9H-xanthen-9-one
InChIKey: JCHQJCJKSHNCBA-UHFFFAOYSA-N
SMILES: C/C(C)=C\CC1=C2C(C(C3=C(C(O)=CC=C3)O2)=O)=C(O)C=C1O
Biological Activity: 1,3,5-Trihydroxy-4-prenylxanthone is a Na+/H+ exchange system inhibitor with a minimum inhibitory concentration of 10 μg/mL[1]. 1,3,5-Trihydroxy-4-prenylxanthone is a phosphodiesterase type 5 (PDE5) inhibitor with an IC50 value of 3.0 μM[3]. 1,3,5-Trihydroxy-4-prenylxanthone inhibits Lipopolysaccharide (LPS) (HY-D1056)-induced NO production in RAW264.7 macrophages, and has anti-inflammatory activities[2].
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1,3,5-Trihydroxy-4-prenylxanthone | 1,3,5-Trihydroxy-4-prenylxanthone is a Na+/H+ exchange system inhibitor with a minimum inhibitory concentration of 10 μg/mL. 1,3,5-Trihydroxy-4-prenylxanthone is a phosphodiesterase type 5 (PDE5) inhibitor with an IC50 value of 3.0 μM. 1,3,5-Trihydroxy-4-prenylxanthone inhibits Lipopolysaccharide (LPS) (HY-D1056)-induced NO production in RAW264.7 macrophages, and has anti-inflammatory activities. | |||||||||||||||||||||
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- [1]. [1] M Kobayashi, et al. Indonesian medicinal plants. XXI. Inhibitors of Na+/H+ exchanger from the bark of Erythrina variegata and the roots of Maclura cochinchinensis. Chem Pharm Bull (Tokyo). 1997 Oct;45(10):1615-9. [Content Brief]
- [2]. Wen-Fei Chiou, et al. 1,3,5-trihydroxy-4-prenylxanthone represses lipopolysaccharide-induced iNOS expression via impeding posttranslational modification of IRAK-1. Biochem Pharmacol. 2011 Mar 15;81(6):752-60. [Content Brief]
- [3]. Chalisa Sabphon, et al. Phosphodiesterase inhibitory activity of the flavonoids and xanthones from Anaxagorea luzonensis. Nat Prod Commun. 2015 Feb;10(2):301-3. [Content Brief]
Keywords
